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GNG7

GENERAL INFORMATION

Gene name

 GNG7

Gene description

 Guanine nucleotide binding protein (G protein), gamma 7

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (REH, U-266/70)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expressed in the CNS, and in immune cells in gastrointestinal mucosa.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA057790
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), lung cancer (favourable), liver cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Lung cancer p<0.001
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057790

GENE INFORMATION

Gene name

 GNG7 (HGNC Symbol)

Synonyms

 FLJ00058

Description

 Guanine nucleotide binding protein (G protein), gamma 7 (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 2511219 - 2702709

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176533 (version 83.38)

Entrez gene

 2788

UniProt

 O60262 (UniProt - Evidence at protein level)

neXtProt

 NX_O60262

Antibodypedia

 GNG7 antibodies

PROTEIN BROWSER
GNG7-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNG7-001
ENSP00000371594
ENST00000382159
O60262 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001662 [behavioral fear response]
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007168 [receptor guanylyl cyclase signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007626 [locomotory behavior]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
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 68 aa
7.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.