Expression of LMNB2 in cancer - Summary - The Human Protein Atlas

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LMNB2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LMNB2
Gene description	Lamin B2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear membrane expression, most abundant in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA047863 , HPA062477 , CAB022593
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), prostate cancer (unfavourable), liver cancer (unfavourable), stomach cancer (favourable) and melanoma (unfavourable).
Renal cancer p<0.001 Prostate cancer p<0.001 Liver cancer p<0.001 Stomach cancer p<0.001 Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Urothelial cancer

STAINING SUMMARY

HPA047863	HPA062477	CAB022593

GENE INFORMATION
Gene name	LMNB2 (HGNC Symbol)
Synonyms	LMN2
Description	Lamin B2 (HGNC Symbol)
Entrez gene summary	This gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in this gene are associated with acquired partial lipodystrophy. [provided by RefSeq, May 2012]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	2427638 - 2456996
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176619 (version 83.38)
Entrez gene	84823
UniProt
neXtProt
Antibodypedia	LMNB2 antibodies

PROTEIN BROWSER

LMNB2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LMNB2-001 ENSP00000327054 ENST00000325327	J9JID7 [Direct mapping] Lamin B2, isoform CRA_a; Lamin-B2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0005638 [lamin filament] GO:0005882 [intermediate filament] Show all	620 aa 69.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.