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Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+, HBF TERT88, U-138 MG)
HPA (normal tissue):
Tissue enhanced (cerebral cortex)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Cytoplasmic expression mainly in CNS.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Essentially all cancer tissues displayed weak cytoplasmic staining or were negative.
GENE INFORMATION
Gene name
BDNF
Synonyms
Description
Brain-derived neurotrophic factor (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]