Cell atlas - ACSF3 - The Human Protein Atlas

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ACSF3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	ACSF3
Gene description	Acyl-CoA synthetase family member 3
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	ACSF3
Synonyms
Description	Acyl-CoA synthetase family member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the acyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation of a thioester linkage between fatty acids and coenzyme A. The encoded protein is localized to mitochondria, has high specificity for malonate and methylmalonate and possesses malonyl-CoA synthetase activity. Mutations in this gene are a cause of combined malonic and methylmalonic aciduria. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Sep 2013]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	89088375 - 89155846
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176715 (version 83.38)
Entrez gene	197322
UniProt	Q4G176 (UniProt - Evidence at protein level)
neXtProt	NX_Q4G176
Antibodypedia	ACSF3 antibodies

PROTEIN BROWSER

ACSF3-001	ACSF3-002	ACSF3-003	ACSF3-009	ACSF3-010	ACSF3-011	ACSF3-012	ACSF3-013	ACSF3-014	ACSF3-015	ACSF3-023	ACSF3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACSF3-001 ENSP00000320646 ENST00000317447	Q4G176 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0006633 [fatty acid biosynthetic process] GO:0008152 [metabolic process] GO:0016878 [acid-thiol ligase activity] GO:0019432 [triglyceride biosynthetic process] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0090409 [malonyl-CoA synthetase activity] GO:0090410 [malonate catabolic process] Show all	576 aa 64.1 kDa	No	1
ACSF3-002 ENSP00000367596 ENST00000378345	F5H5A1 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	311 aa 35.1 kDa	No	0
ACSF3-003 ENSP00000384627 ENST00000406948	Q4G176 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0006633 [fatty acid biosynthetic process] GO:0008152 [metabolic process] GO:0016878 [acid-thiol ligase activity] GO:0019432 [triglyceride biosynthetic process] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0090409 [malonyl-CoA synthetase activity] GO:0090410 [malonate catabolic process] Show all	576 aa 64.1 kDa	No	1
ACSF3-009 ENSP00000440734 ENST00000537290	F5GX20 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	237 aa 26 kDa	No	0
ACSF3-010 ENSP00000445397 ENST00000540697	F5H362 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	190 aa 21.5 kDa	No	0
ACSF3-011 ENSP00000439201 ENST00000537895	F5H3B2 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	106 aa 12.2 kDa	No	0
ACSF3-012 ENSP00000442781 ENST00000544543	F5H755 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	235 aa 26.6 kDa	No	0
ACSF3-013 ENSP00000443428 ENST00000535176	H0YGJ0 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		106 aa 12 kDa	No	0
ACSF3-014 ENSP00000442683 ENST00000543676	H0YGC7 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	183 aa 20.3 kDa	No	0
ACSF3-015 ENSP00000445870 ENST00000538340	H0YH37 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	144 aa 16.7 kDa	No	0
ACSF3-023 ENSP00000457301 ENST00000541755	H3BTS0 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		28 aa 3.1 kDa	No	0
ACSF3-201 ENSP00000479130 ENST00000614302	Q4G176 [Direct mapping] Acyl-CoA synthetase family member 3, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006631 [fatty acid metabolic process] GO:0006633 [fatty acid biosynthetic process] GO:0008152 [metabolic process] GO:0016878 [acid-thiol ligase activity] GO:0019432 [triglyceride biosynthetic process] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0090409 [malonyl-CoA synthetase activity] GO:0090410 [malonate catabolic process] Show all	576 aa 64.1 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.