Expression of MAGEB6 in cancer - Summary - The Human Protein Atlas

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MAGEB6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAGEB6
Gene description	Melanoma antigen family B6
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Cell line enriched (K-562)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in trophoblasts of placenta and basal cells in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA041853
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041853

GENE INFORMATION
Gene name	MAGEB6 (HGNC Symbol)
Synonyms	CT3.4, FLJ40242, MAGE-B6, MAGEB6A
Description	Melanoma antigen family B6 (HGNC Symbol)
Entrez gene summary	This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is expressed in testis, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	p21.3
Chromosome location (bp)	26192440 - 26195646
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176746 (version 83.38)
Entrez gene	158809
UniProt	Q8N7X4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N7X4
Antibodypedia	MAGEB6 antibodies

PROTEIN BROWSER

MAGEB6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAGEB6-001 ENSP00000368320 ENST00000379034	Q8N7X4 [Direct mapping] Melanoma-associated antigen B6 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	407 aa 44 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.