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TYMS

GENERAL INFORMATION

Gene name

 TYMS

Gene description

 Thymidylate synthetase

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression, most abundant in lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB002784
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Cerebellum
N/A
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 TYMS (HGNC Symbol)

Synonyms

 HsT422, TMS, TS, Tsase

Description

 Thymidylate synthetase (HGNC Symbol)

Entrez gene summary

 Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 p11.32

Chromosome location (bp)

 657604 - 673578

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176890 (version 83.38)

Entrez gene

 7298

UniProt

 P04818 (UniProt - Evidence at protein level)

neXtProt

 NX_P04818

Antibodypedia

 TYMS antibodies

PROTEIN BROWSER
TYMS-001
TYMS-002
TYMS-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TYMS-001
ENSP00000315644
ENST00000323274
P04818 [Direct mapping]
Thymidylate synthase
Q53Y97 [Target identity:100%; Query identity:100%]
Thymidylate synthetase; Thymidylate synthetase, isoform CRA_f; cDNA, FLJ94841, Homo sapiens thymidylate synthetase (TYMS), mRNA
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0000278 [mitotic cell cycle]
GO:0003729 [mRNA binding]
GO:0004799 [thymidylate synthase activity]
GO:0005542 [folic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006231 [dTMP biosynthetic process]
GO:0006235 [dTTP biosynthetic process]
GO:0007568 [aging]
GO:0007623 [circadian rhythm]
GO:0008144 [drug binding]
GO:0008283 [cell proliferation]
GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process]
GO:0009636 [response to toxic substance]
GO:0014070 [response to organic cyclic compound]
GO:0016049 [cell growth]
GO:0019088 [immortalization of host cell by virus]
GO:0019860 [uracil metabolic process]
GO:0031100 [organ regeneration]
GO:0032259 [methylation]
GO:0032570 [response to progesterone]
GO:0033189 [response to vitamin A]
GO:0034097 [response to cytokine]
GO:0035999 [tetrahydrofolate interconversion]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045471 [response to ethanol]
GO:0046078 [dUMP metabolic process]
GO:0046134 [pyrimidine nucleoside biosynthetic process]
GO:0046653 [tetrahydrofolate metabolic process]
GO:0046683 [response to organophosphorus]
GO:0048037 [cofactor binding]
GO:0048589 [developmental growth]
GO:0051216 [cartilage development]
GO:0051384 [response to glucocorticoid]
GO:0051593 [response to folic acid]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0060574 [intestinal epithelial cell maturation]
GO:0071897 [DNA biosynthetic process]
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 313 aa
35.7 kDa 		No 0
TYMS-002
ENSP00000314727
ENST00000323224
P04818 [Direct mapping]
Thymidylate synthase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004799 [thymidylate synthase activity]
GO:0005542 [folic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006231 [dTMP biosynthetic process]
GO:0006235 [dTTP biosynthetic process]
GO:0008283 [cell proliferation]
GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process]
GO:0016049 [cell growth]
GO:0032259 [methylation]
GO:0035999 [tetrahydrofolate interconversion]
GO:0044281 [small molecule metabolic process]
GO:0046134 [pyrimidine nucleoside biosynthetic process]
GO:0046683 [response to organophosphorus]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0071897 [DNA biosynthetic process]
Show all
 279 aa
31.8 kDa 		No 0
TYMS-003
ENSP00000314902
ENST00000323250
P04818 [Direct mapping]
Thymidylate synthase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0004799 [thymidylate synthase activity]
GO:0005542 [folic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006231 [dTMP biosynthetic process]
GO:0006235 [dTTP biosynthetic process]
GO:0008283 [cell proliferation]
GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process]
GO:0016049 [cell growth]
GO:0032259 [methylation]
GO:0035999 [tetrahydrofolate interconversion]
GO:0044281 [small molecule metabolic process]
GO:0046134 [pyrimidine nucleoside biosynthetic process]
GO:0046683 [response to organophosphorus]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0071897 [DNA biosynthetic process]
Show all
 230 aa
26.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.