Fields »
ABOUT
HELP
BLOG
ANKLE2

GENERAL INFORMATION

Gene name

 ANKLE2

Gene description

 Ankyrin repeat and LEM domain containing 2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in selected tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA003602
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003602

GENE INFORMATION

Gene name

 ANKLE2 (HGNC Symbol)

Synonyms

 KIAA0692, Lem4, LEMD7

Description

 Ankyrin repeat and LEM domain containing 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014]

Chromosome

 12

Cytoband

 q24.33

Chromosome location (bp)

 132725503 - 132761888

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176915 (version 83.38)

Entrez gene

 23141

UniProt

 Q86XL3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86XL3

Antibodypedia

 ANKLE2 antibodies

PROTEIN BROWSER
ANKLE2-001
ANKLE2-003
ANKLE2-008
ANKLE2-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANKLE2-001
ENSP00000350686
ENST00000357997
Q86XL3 [Direct mapping]
Ankyrin repeat and LEM domain-containing protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0007067 [mitotic nuclear division]
GO:0007084 [mitotic nuclear envelope reassembly]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0016020 [membrane]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042326 [negative regulation of phosphorylation]
GO:0050790 [regulation of catalytic activity]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 938 aa
104.1 kDa 		No 1
ANKLE2-003
ENSP00000438551
ENST00000542657
Q86XL3 [Direct mapping]
Ankyrin repeat and LEM domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0007067 [mitotic nuclear division]
GO:0007084 [mitotic nuclear envelope reassembly]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0016020 [membrane]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042326 [negative regulation of phosphorylation]
GO:0050790 [regulation of catalytic activity]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 293 aa
32 kDa 		No 0
ANKLE2-008
ENSP00000445760
ENST00000538766
F5H1D4 [Direct mapping]
Ankyrin repeat and LEM domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 258 aa
28.4 kDa 		No 0
ANKLE2-014
ENSP00000437807
ENST00000542282
Q86XL3 [Direct mapping]
Ankyrin repeat and LEM domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0007067 [mitotic nuclear division]
GO:0007084 [mitotic nuclear envelope reassembly]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0016020 [membrane]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0035307 [positive regulation of protein dephosphorylation]
GO:0042326 [negative regulation of phosphorylation]
GO:0050790 [regulation of catalytic activity]
GO:0051301 [cell division]
GO:0051721 [protein phosphatase 2A binding]
Show all
 293 aa
32 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.