Cell atlas - FUT2 - The Human Protein Atlas

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FUT2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	FUT2
Gene description	Fucosyltransferase 2 (secretor status included)
Protein class	Blood group antigen proteins Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Cell line enriched (CAPAN-2)
Protein evidence	Evidence at transcript level
Main location	Localized to the Plasma membrane (uncertain), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA014402
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (CAPAN-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014402	A-431	Plasma membrane
	HPA014402	A-431	Cytosol
	HPA014402	CACO-2	Plasma membrane
	HPA014402	CACO-2	Cytosol
	HPA014402	U-2 OS	Plasma membrane
	HPA014402	U-2 OS	Cytosol

GENE INFORMATION
Gene name	FUT2 (HGNC Symbol)
Synonyms	SE, Se2, SEC2, sej
Description	Fucosyltransferase 2 (secretor status included) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	48695971 - 48705950
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000176920 (version 83.38)
Entrez gene	2524
UniProt	Q10981 (UniProt - Evidence at transcript level)
neXtProt	NX_Q10981
Antibodypedia	FUT2 antibodies

PROTEIN BROWSER

FUT2-001	FUT2-002	FUT2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FUT2-001 ENSP00000387498 ENST00000425340	Q10981 [Direct mapping] Galactoside 2-alpha-L-fucosyltransferase 2 A8K2L2 [Target identity:100%; Query identity:100%] Fucosyltransferase; HCG1998026, isoform CRA_a; cDNA FLJ75308, highly similar to Human alpha(1,2)fucosyltransferase (FUT2) gene Show all	Enzymes ENZYME proteins Transferases Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0008107 [galactoside 2-alpha-L-fucosyltransferase activity] GO:0008417 [fucosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032580 [Golgi cisterna membrane] GO:0036065 [fucosylation] GO:0042355 [L-fucose catabolic process] GO:0070062 [extracellular exosome] Show all	343 aa 39 kDa	No	2
FUT2-002 ENSP00000430227 ENST00000522966	E7EW73 [Direct mapping] Galactoside 2-alpha-L-fucosyltransferase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005975 [carbohydrate metabolic process] GO:0008107 [galactoside 2-alpha-L-fucosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0036065 [fucosylation] Show all	220 aa 25.4 kDa	No	1
FUT2-201 ENSP00000375748 ENST00000391876	Q10981 [Direct mapping] Galactoside 2-alpha-L-fucosyltransferase 2 A8K2L2 [Target identity:100%; Query identity:100%] Fucosyltransferase; HCG1998026, isoform CRA_a; cDNA FLJ75308, highly similar to Human alpha(1,2)fucosyltransferase (FUT2) gene Show all	Enzymes ENZYME proteins Transferases Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006486 [protein glycosylation] GO:0008107 [galactoside 2-alpha-L-fucosyltransferase activity] GO:0008417 [fucosyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0032580 [Golgi cisterna membrane] GO:0036065 [fucosylation] GO:0042355 [L-fucose catabolic process] GO:0070062 [extracellular exosome] Show all	343 aa 39 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.