Expression of FIBIN in cancer - Summary - The Human Protein Atlas

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FIBIN

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FIBIN
Gene description	Fin bud initiation factor homolog (zebrafish)
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (ASC TERT1, hTCEpi)
HPA (normal tissue):	Tissue enhanced (seminal vesicle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA040120
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable), renal cancer (favourable) and stomach cancer (unfavourable).
Thyroid cancer p<0.001 Renal cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040120

GENE INFORMATION
Gene name	FIBIN (HGNC Symbol)
Synonyms	MGC24932
Description	Fin bud initiation factor homolog (zebrafish) (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p14.2
Chromosome location (bp)	26994184 - 26996121
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176971 (version 83.38)
Entrez gene	387758
UniProt	Q8TAL6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TAL6
Antibodypedia	FIBIN antibodies

PROTEIN BROWSER

FIBIN-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FIBIN-001 ENSP00000321962 ENST00000318627	Q8TAL6 [Direct mapping] Fin bud initiation factor homolog Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] Show all	211 aa 24.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.