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FAM89B

GENERAL INFORMATION

Gene name

 FAM89B

Gene description

 Family with sequence similarity 89, member B

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA046895
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and ovarian cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046895

GENE INFORMATION

Gene name

 FAM89B

Synonyms

Description

 Family with sequence similarity 89, member B (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65572349 - 65574198

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000176973 (version 83.38)

Entrez gene

 23625

UniProt

 Q8N5H3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N5H3

Antibodypedia

 FAM89B antibodies

PROTEIN BROWSER
FAM89B-001
FAM89B-002
FAM89B-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FAM89B-001
ENSP00000314829
ENST00000316409
Q8N5H3 [Direct mapping]
Protein FAM89B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001222 [transcription corepressor binding]
GO:0005737 [cytoplasm]
GO:0009986 [cell surface]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0060392 [negative regulation of SMAD protein import into nucleus]
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 176 aa
18.7 kDa 		No 0
FAM89B-002
ENSP00000402439
ENST00000449319
Q8N5H3 [Direct mapping]
Protein FAM89B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001222 [transcription corepressor binding]
GO:0005737 [cytoplasm]
GO:0009986 [cell surface]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0060392 [negative regulation of SMAD protein import into nucleus]
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 154 aa
15.4 kDa 		No 0
FAM89B-004
ENSP00000431459
ENST00000530349
Q8N5H3 [Direct mapping]
Protein FAM89B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001222 [transcription corepressor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0009986 [cell surface]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0060392 [negative regulation of SMAD protein import into nucleus]
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 189 aa
20.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.