Tissue expression of SHMT1 - Summary - The Human Protein Atlas

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SHMT1

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SHMT1
Gene description	Serine hydroxymethyltransferase 1 (soluble)
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA023314
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SHMT1 (HGNC Symbol)
Synonyms	CSHMT, MGC15229, MGC24556, SHMT
Description	Serine hydroxymethyltransferase 1 (soluble) (HGNC Symbol)
Entrez gene summary	This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	18327860 - 18363563
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000176974 (version 83.38)
Entrez gene	6470
UniProt	P34896 (UniProt - Evidence at protein level)
neXtProt	NX_P34896
Antibodypedia	SHMT1 antibodies

PROTEIN BROWSER

SHMT1-001	SHMT1-003	SHMT1-007	SHMT1-009	SHMT1-201	SHMT1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SHMT1-001 ENSP00000318868 ENST00000316694	P34896 [Direct mapping] Serine hydroxymethyltransferase, cytosolic Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004372 [glycine hydroxymethyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006231 [dTMP biosynthetic process] GO:0006544 [glycine metabolic process] GO:0006545 [glycine biosynthetic process] GO:0006563 [L-serine metabolic process] GO:0006565 [L-serine catabolic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0008732 [L-allo-threonine aldolase activity] GO:0009083 [branched-chain amino acid catabolic process] GO:0009113 [purine nucleobase biosynthetic process] GO:0016597 [amino acid binding] GO:0016740 [transferase activity] GO:0019264 [glycine biosynthetic process from serine] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035999 [tetrahydrofolate interconversion] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0045329 [carnitine biosynthetic process] GO:0046655 [folic acid metabolic process] GO:0051262 [protein tetramerization] GO:0051289 [protein homotetramerization] GO:0070062 [extracellular exosome] GO:0070905 [serine binding] GO:1904482 [cellular response to tetrahydrofolate] Show all	483 aa 53.1 kDa	No	0
SHMT1-003 ENSP00000318805 ENST00000354098	P34896 [Direct mapping] Serine hydroxymethyltransferase, cytosolic Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004372 [glycine hydroxymethyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006544 [glycine metabolic process] GO:0006563 [L-serine metabolic process] GO:0006565 [L-serine catabolic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0009083 [branched-chain amino acid catabolic process] GO:0009113 [purine nucleobase biosynthetic process] GO:0016740 [transferase activity] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035999 [tetrahydrofolate interconversion] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0045329 [carnitine biosynthetic process] GO:0046655 [folic acid metabolic process] GO:0051262 [protein tetramerization] GO:0070062 [extracellular exosome] GO:0070905 [serine binding] GO:1904482 [cellular response to tetrahydrofolate] Show all	444 aa 49 kDa	No	0
SHMT1-007 ENSP00000462041 ENST00000583780		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1 aa 0.1 kDa	No	0
SHMT1-009 ENSP00000462227 ENST00000582653	J3KRZ5 [Direct mapping] Serine hydroxymethyltransferase, cytosolic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0016740 [transferase activity] Show all	167 aa 18.6 kDa	No	0
SHMT1-201 ENSP00000345881 ENST00000352886	P34896 [Direct mapping] Serine hydroxymethyltransferase, cytosolic Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004372 [glycine hydroxymethyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006544 [glycine metabolic process] GO:0006563 [L-serine metabolic process] GO:0006565 [L-serine catabolic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0009083 [branched-chain amino acid catabolic process] GO:0009113 [purine nucleobase biosynthetic process] GO:0016740 [transferase activity] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035999 [tetrahydrofolate interconversion] GO:0042803 [protein homodimerization activity] GO:0044281 [small molecule metabolic process] GO:0045329 [carnitine biosynthetic process] GO:0046655 [folic acid metabolic process] GO:0051262 [protein tetramerization] GO:0070062 [extracellular exosome] GO:0070905 [serine binding] GO:1904482 [cellular response to tetrahydrofolate] Show all	345 aa 37.7 kDa	No	0
SHMT1-202 ENSP00000477782 ENST00000618902	A0A087WTD8 [Direct mapping] Serine hydroxymethyltransferase, cytosolic Show all	SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016740 [transferase activity] Show all	125 aa 13.7 kDa	No	0

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The Human Protein Atlas

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by the Knut & Alice Wallenberg foundation.