Expression of DEFB104B in cancer - Summary - The Human Protein Atlas

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DEFB104B

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DEFB104B
Gene description	Defensin, beta 104B
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective extracellular positivity in epididymis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 1 antibody. HPA045292
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045292

GENE INFORMATION
Gene name	DEFB104B
Synonyms
Description	Defensin, beta 104B (HGNC Symbol)
Entrez gene summary	Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]
Chromosome	8
Cytoband	p23.1
Chromosome location (bp)	7470308 - 7475082
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177023 (version 83.38)
Entrez gene	503618
UniProt	Q8WTQ1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WTQ1
Antibodypedia	DEFB104B antibodies

PROTEIN BROWSER

DEFB104B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEFB104B-001 ENSP00000322191 ENST00000316169	Q8WTQ1 [Direct mapping] Beta-defensin 104 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0009986 [cell surface] GO:0042742 [defense response to bacterium] GO:0045087 [innate immune response] Show all	72 aa 8.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.