Expression of C19orf18 in cancer - Summary - The Human Protein Atlas

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C19orf18

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C19orf18
Gene description	Chromosome 19 open reading frame 18
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEK93)
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA014527
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014527

Cancer	Cancer staining
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Moderate cytoplasmic positivity, often with a granular pattern, was observed in most malignant cells. Skin cancers and malignant lymphomas were weakly stained or negative.

GENE INFORMATION
Gene name	C19orf18 (HGNC Symbol)
Synonyms	MGC41906
Description	Chromosome 19 open reading frame 18 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.43
Chromosome location (bp)	57958437 - 57974534
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000177025 (version 83.38)
Entrez gene	147685
UniProt	Q8NEA5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NEA5
Antibodypedia	C19orf18 antibodies

PROTEIN BROWSER

C19orf18-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C19orf18-001 ENSP00000321519 ENST00000314391	Q8NEA5 [Direct mapping] Uncharacterized protein C19orf18 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	215 aa 24.2 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.