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DEAF1

GENERAL INFORMATION

Gene name

 DEAF1

Gene description

 DEAF1 transcription factor

Protein class

 Disease related genes
Predicted secreted proteins
Transcription factors

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA030302
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030302

GENE INFORMATION

Gene name

 DEAF1 (HGNC Symbol)

Synonyms

 NUDR, SPN, ZMYND5

Description

 DEAF1 transcription factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 644233 - 706715

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177030 (version 83.38)

Entrez gene

 10522

UniProt

 O75398 (UniProt - Evidence at protein level)

neXtProt

 NX_O75398

Antibodypedia

 DEAF1 antibodies

PROTEIN BROWSER
DEAF1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DEAF1-001
ENSP00000371846
ENST00000382409
O75398 [Direct mapping]
Deformed epidermal autoregulatory factor 1 homolog
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   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Transcription factors
   alpha-Helices exposed by beta-structures
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001662 [behavioral fear response]
GO:0001843 [neural tube closure]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007281 [germ cell development]
GO:0008542 [visual learning]
GO:0009653 [anatomical structure morphogenesis]
GO:0033599 [regulation of mammary gland epithelial cell proliferation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048706 [embryonic skeletal system development]
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 565 aa
59.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.