Expression of MTX3 in cancer - Summary - The Human Protein Atlas

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MTX3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MTX3
Gene description	Metaxin 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA047858
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and ovarian cancer (unfavourable).
Liver cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047858

GENE INFORMATION
Gene name	MTX3
Synonyms
Description	Metaxin 3 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q14.1
Chromosome location (bp)	79976731 - 79991262
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177034 (version 83.38)
Entrez gene	345778
UniProt	Q5HYI7 (UniProt - Evidence at protein level)
neXtProt	NX_Q5HYI7
Antibodypedia	MTX3 antibodies

PROTEIN BROWSER

MTX3-001	MTX3-002	MTX3-005	MTX3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTX3-001 ENSP00000423302 ENST00000509852	Q5HYI7 [Direct mapping] Metaxin-3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005741 [mitochondrial outer membrane] GO:0006626 [protein targeting to mitochondrion] Show all	248 aa 27.9 kDa	No	0
MTX3-002 ENSP00000423600 ENST00000512560	Q5HYI7 [Direct mapping] Metaxin-3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005741 [mitochondrial outer membrane] GO:0006626 [protein targeting to mitochondrion] Show all	251 aa 28.6 kDa	No	0
MTX3-005 ENSP00000424798 ENST00000512528	Q5HYI7 [Direct mapping] Metaxin-3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005741 [mitochondrial outer membrane] GO:0006626 [protein targeting to mitochondrion] Show all	312 aa 35.1 kDa	No	0
MTX3-201 ENSP00000484157 ENST00000617335	Q5HYI7 [Direct mapping] Metaxin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005741 [mitochondrial outer membrane] GO:0006626 [protein targeting to mitochondrion] Show all	158 aa 17.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.