Tissue expression of FBXO46 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FBXO46
Gene description	F-box protein 46
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA049390
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	FBXO46 (HGNC Symbol)
Synonyms	20D7-FC4, Fbx46, FBXO34L
Description	F-box protein 46 (HGNC Symbol)
Entrez gene summary	Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	45710629 - 45730904
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177051 (version 83.38)
Entrez gene	23403
UniProt	Q6PJ61 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PJ61
Antibodypedia	FBXO46 antibodies

PROTEIN BROWSER

FBXO46-001	FBXO46-003	FBXO46-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXO46-001 ENSP00000410007 ENST00000317683	Q6PJ61 [Direct mapping] F-box only protein 46 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	603 aa 64.6 kDa	No	0
FBXO46-003 ENSP00000465591 ENST00000591686	K7EKF1 [Direct mapping] F-box only protein 46 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		13 aa 1.6 kDa	No	0
FBXO46-004 ENSP00000468336 ENST00000586899	K7ERN4 [Direct mapping] F-box only protein 46 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		184 aa 19.2 kDa	No	0