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SCN4B

GENERAL INFORMATION

Gene name

 SCN4B

Gene description

 Sodium channel, voltage gated, type IV beta subunit

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adipose tissue)
GTEx:Tissue enhanced (caudate, cerebellum)
FANTOM5:Group enriched (caudate, cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in all tissues at variable levels.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA017293
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebellum)

GENE INFORMATION

Gene name

 SCN4B (HGNC Symbol)

Synonyms

 LQT10

Description

 Sodium channel, voltage gated, type IV beta subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 118133377 - 118152888

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177098 (version 83.38)

Entrez gene

 6330

UniProt

 Q8IWT1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IWT1

Antibodypedia

 SCN4B antibodies

PROTEIN BROWSER
SCN4B-001
SCN4B-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCN4B-001
ENSP00000322460
ENST00000324727
Q8IWT1 [Direct mapping]
Sodium channel subunit beta-4
B0YJ93 [Target identity:100%; Query identity:100%]
Sodium channel beta-4 subunit; Sodium channel, voltage-gated, type IV, beta, isoform CRA_b; cDNA, FLJ95353, Homo sapiens sodium channel, voltage-gated, type IV, beta (SCN4B),mRNA
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Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006814 [sodium ion transport]
GO:0010765 [positive regulation of sodium ion transport]
GO:0014704 [intercalated disc]
GO:0017080 [sodium channel regulator activity]
GO:0031226 [intrinsic component of plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0044325 [ion channel binding]
GO:0060048 [cardiac muscle contraction]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086016 [AV node cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
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 228 aa
25 kDa 		Yes 1
SCN4B-004
ENSP00000436343
ENST00000529878
Q8IWT1 [Direct mapping]
Sodium channel subunit beta-4
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Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0005248 [voltage-gated sodium channel activity]
GO:0006814 [sodium ion transport]
GO:0010765 [positive regulation of sodium ion transport]
GO:0014704 [intercalated disc]
GO:0017080 [sodium channel regulator activity]
GO:0031226 [intrinsic component of plasma membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0044325 [ion channel binding]
GO:0060048 [cardiac muscle contraction]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0086002 [cardiac muscle cell action potential involved in contraction]
GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential]
GO:0086012 [membrane depolarization during cardiac muscle cell action potential]
GO:0086016 [AV node cell action potential]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:2000649 [regulation of sodium ion transmembrane transporter activity]
Show all
 94 aa
9.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.