Fields »
ABOUT
HELP
BLOG
ANO6

GENERAL INFORMATION

Gene name

 ANO6

Gene description

 Anoctamin 6

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA038958
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable) and cervical cancer (unfavourable).
Breast cancer p<0.001
Cervical cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038958

GENE INFORMATION

Gene name

 ANO6 (HGNC Symbol)

Synonyms

 DKFZp313M0720, TMEM16F

Description

 Anoctamin 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Chromosome

 12

Cytoband

 q12

Chromosome location (bp)

 45215987 - 45440404

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177119 (version 83.38)

Entrez gene

 196527

UniProt

 Q4KMQ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q4KMQ2

Antibodypedia

 ANO6 antibodies

PROTEIN BROWSER
ANO6-001
ANO6-002
ANO6-003
ANO6-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANO6-001
ENSP00000320087
ENST00000320560
Q4KMQ2 [Direct mapping]
Anoctamin-6
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002543 [activation of blood coagulation via clotting cascade]
GO:0005227 [calcium activated cation channel activity]
GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005244 [voltage-gated ion channel activity]
GO:0005247 [voltage-gated chloride channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006821 [chloride transport]
GO:0006869 [lipid transport]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0017121 [phospholipid scrambling]
GO:0030501 [positive regulation of bone mineralization]
GO:0032060 [bleb assembly]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0034767 [positive regulation of ion transmembrane transport]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0035725 [sodium ion transmembrane transport]
GO:0043065 [positive regulation of apoptotic process]
GO:0045794 [negative regulation of cell volume]
GO:0046931 [pore complex assembly]
GO:0055085 [transmembrane transport]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097045 [phosphatidylserine exposure on blood platelet]
GO:1902476 [chloride transmembrane transport]
GO:1903959 [regulation of anion transmembrane transport]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
Show all
 910 aa
106.2 kDa 		No 9
ANO6-002
ENSP00000391417
ENST00000425752
Q4KMQ2 [Direct mapping]
Anoctamin-6
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002543 [activation of blood coagulation via clotting cascade]
GO:0005227 [calcium activated cation channel activity]
GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005244 [voltage-gated ion channel activity]
GO:0005247 [voltage-gated chloride channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006821 [chloride transport]
GO:0006869 [lipid transport]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0017121 [phospholipid scrambling]
GO:0030501 [positive regulation of bone mineralization]
GO:0032060 [bleb assembly]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0034767 [positive regulation of ion transmembrane transport]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0035725 [sodium ion transmembrane transport]
GO:0043065 [positive regulation of apoptotic process]
GO:0045794 [negative regulation of cell volume]
GO:0046931 [pore complex assembly]
GO:0055085 [transmembrane transport]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097045 [phosphatidylserine exposure on blood platelet]
GO:1902476 [chloride transmembrane transport]
GO:1903959 [regulation of anion transmembrane transport]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
Show all
 929 aa
108.1 kDa 		No >9
ANO6-003
ENSP00000413137
ENST00000441606
Q4KMQ2 [Direct mapping]
Anoctamin-6
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002543 [activation of blood coagulation via clotting cascade]
GO:0005227 [calcium activated cation channel activity]
GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005244 [voltage-gated ion channel activity]
GO:0005247 [voltage-gated chloride channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006821 [chloride transport]
GO:0006869 [lipid transport]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0017121 [phospholipid scrambling]
GO:0030501 [positive regulation of bone mineralization]
GO:0032060 [bleb assembly]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0034767 [positive regulation of ion transmembrane transport]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0035725 [sodium ion transmembrane transport]
GO:0043065 [positive regulation of apoptotic process]
GO:0045794 [negative regulation of cell volume]
GO:0046931 [pore complex assembly]
GO:0055085 [transmembrane transport]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097045 [phosphatidylserine exposure on blood platelet]
GO:1902476 [chloride transmembrane transport]
GO:1903959 [regulation of anion transmembrane transport]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
Show all
 892 aa
104 kDa 		No 9
ANO6-005
ENSP00000409126
ENST00000423947
Q4KMQ2 [Direct mapping]
Anoctamin-6
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002407 [dendritic cell chemotaxis]
GO:0002543 [activation of blood coagulation via clotting cascade]
GO:0005227 [calcium activated cation channel activity]
GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005244 [voltage-gated ion channel activity]
GO:0005247 [voltage-gated chloride channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006821 [chloride transport]
GO:0006869 [lipid transport]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0017121 [phospholipid scrambling]
GO:0017128 [phospholipid scramblase activity]
GO:0030501 [positive regulation of bone mineralization]
GO:0032060 [bleb assembly]
GO:0034220 [ion transmembrane transport]
GO:0034707 [chloride channel complex]
GO:0034767 [positive regulation of ion transmembrane transport]
GO:0035590 [purinergic nucleotide receptor signaling pathway]
GO:0035630 [bone mineralization involved in bone maturation]
GO:0035725 [sodium ion transmembrane transport]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0045794 [negative regulation of cell volume]
GO:0046931 [pore complex assembly]
GO:0055085 [transmembrane transport]
GO:0060100 [positive regulation of phagocytosis, engulfment]
GO:0061588 [calcium activated phospholipid scrambling]
GO:0061589 [calcium activated phosphatidylserine scrambling]
GO:0061590 [calcium activated phosphatidylcholine scrambling]
GO:0061591 [calcium activated galactosylceramide scrambling]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097045 [phosphatidylserine exposure on blood platelet]
GO:1902476 [chloride transmembrane transport]
GO:1903959 [regulation of anion transmembrane transport]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
Show all
 931 aa
108.4 kDa 		No 9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.