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RPS6KA3

GENERAL INFORMATION

Gene name

 RPS6KA3

Gene description

 Ribosomal protein S6 kinase, 90kDa, polypeptide 3

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear or cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA003221 , CAB003853 , CAB013520
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003221
CAB003853
CAB013520

GENE INFORMATION

Gene name

 RPS6KA3 (HGNC Symbol)

Synonyms

 CLS, HU-3, MRX19, RSK, RSK2

Description

 Ribosomal protein S6 kinase, 90kDa, polypeptide 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 p22.12

Chromosome location (bp)

 20149911 - 20267100

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177189 (version 83.38)

Entrez gene

 6197

UniProt

 P51812 (UniProt - Evidence at protein level)

neXtProt

 NX_P51812

Antibodypedia

 RPS6KA3 antibodies

PROTEIN BROWSER
RPS6KA3-001
RPS6KA3-002
RPS6KA3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPS6KA3-001
ENSP00000368884
ENST00000379565
P51812 [Direct mapping]
Ribosomal protein S6 kinase alpha-3
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0001501 [skeletal system development]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007417 [central nervous system development]
GO:0019901 [protein kinase binding]
GO:0030307 [positive regulation of cell growth]
GO:0032496 [response to lipopolysaccharide]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043555 [regulation of translation in response to stress]
GO:0043620 [regulation of DNA-templated transcription in response to stress]
GO:0045087 [innate immune response]
GO:0045597 [positive regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
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 740 aa
83.7 kDa 		No 0
RPS6KA3-002
ENSP00000407655
ENST00000457145
B1AXG1 [Direct mapping]
Ribosomal protein S6 kinase alpha-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0035556 [intracellular signal transduction]
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 227 aa
26.2 kDa 		No 0
RPS6KA3-003
ENSP00000388512
ENST00000438357
B1AXG2 [Direct mapping]
Ribosomal protein S6 kinase alpha-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0035556 [intracellular signal transduction]
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 133 aa
15.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.