Expression of MAN1B1 in cancer - Summary - The Human Protein Atlas

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MAN1B1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAN1B1
Gene description	Mannosidase, alpha, class 1B, member 1
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern /BK

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA051516
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051516

GENE INFORMATION
Gene name	MAN1B1 (HGNC Symbol)
Synonyms	MANA-ER, MRT15
Description	Mannosidase, alpha, class 1B, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	137086927 - 137109187
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177239 (version 83.38)
Entrez gene	11253
UniProt	Q9UKM7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UKM7
Antibodypedia	MAN1B1 antibodies

PROTEIN BROWSER

MAN1B1-003	MAN1B1-004	MAN1B1-008	MAN1B1-015	MAN1B1-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAN1B1-003 ENSP00000448658 ENST00000475449	H0YI64 [Direct mapping] Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0008152 [metabolic process] GO:0016020 [membrane] Show all	270 aa 29.5 kDa	No	0
MAN1B1-004 ENSP00000360645 ENST00000371589	Q9UKM7 [Direct mapping] Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0006457 [protein folding] GO:0006487 [protein N-linked glycosylation] GO:0006491 [N-glycan processing] GO:0009311 [oligosaccharide metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0036508 [protein alpha-1,2-demannosylation] GO:0036509 [trimming of terminal mannose on B branch] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044322 [endoplasmic reticulum quality control compartment] GO:0097466 [glycoprotein ERAD pathway] GO:1903561 [extracellular vesicle] GO:1904380 [endoplasmic reticulum mannose trimming] GO:1904382 [mannose trimming involved in glycoprotein ERAD pathway] Show all	699 aa 79.6 kDa	No	1
MAN1B1-008 ENSP00000441398 ENST00000535144	H0YG20 [Direct mapping] alpha-1,2-Mannosidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	695 aa 79 kDa	No	1
MAN1B1-015 ENSP00000444189 ENST00000542372	H0YGQ1 [Direct mapping] Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	182 aa 20.8 kDa	No	1
MAN1B1-017 ENSP00000450147 ENST00000550113	H0YIU0 [Direct mapping] Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0008152 [metabolic process] GO:0016020 [membrane] Show all	124 aa 14.6 kDa	No	0

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