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DEFB4B

GENERAL INFORMATION

Gene name

 DEFB4B

Gene description

 Defensin, beta 4B

Protein class

 Predicted secreted proteins
Transporters

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (tonsil)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DEFB4B (HGNC Symbol)

Synonyms

 DEFB4P

Description

 Defensin, beta 4B (HGNC Symbol)

Entrez gene summary

 Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 4, an antibiotic peptide which is locally regulated by inflammation. [provided by RefSeq, Oct 2014]

Chromosome

 8

Cytoband

 p23.1

Chromosome location (bp)

 7414860 - 7416863

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177257 (version 83.38)

Entrez gene

 100289462

UniProt

 O15263 (UniProt - Evidence at protein level)

neXtProt

 NX_O15263

Antibodypedia

 DEFB4B antibodies

PROTEIN BROWSER
DEFB4B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DEFB4B-001
ENSP00000424598
ENST00000318157
O15263 [Direct mapping]
Beta-defensin 4A
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Transporters
   Transporter channels and pores
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0005576 [extracellular region]
GO:0005796 [Golgi lumen]
GO:0006935 [chemotaxis]
GO:0006952 [defense response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0045087 [innate immune response]
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 64 aa
7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.