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KCNA3

GENERAL INFORMATION

Gene name

 KCNA3

Gene description

 Potassium channel, voltage gated shaker related subfamily A, member 3

Protein class

 FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HDLM-2, Karpas-707, U-266/70, U-266/84)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in astrocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Approved based on 1 antibody.
HPA016625
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA016625

GENE INFORMATION

Gene name

 KCNA3 (HGNC Symbol)

Synonyms

 HLK3, HPCN3, Kv1.3, MK3

Description

 Potassium channel, voltage gated shaker related subfamily A, member 3 (HGNC Symbol)

Entrez gene summary

 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 110672465 - 110675033

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177272 (version 83.38)

Entrez gene

 3738

UniProt

 P22001 (UniProt - Evidence at protein level)

neXtProt

 NX_P22001

Antibodypedia

 KCNA3 antibodies

PROTEIN BROWSER
KCNA3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNA3-001
ENSP00000358784
ENST00000369769
P22001 [Direct mapping]
Potassium voltage-gated channel subfamily A member 3
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
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GO:0005216 [ion channel activity]
GO:0005244 [voltage-gated ion channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015271 [outward rectifier potassium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030424 [axon]
GO:0034765 [regulation of ion transmembrane transport]
GO:0045121 [membrane raft]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
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 575 aa
63.8 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.