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Pancreatic cancers, a few gliomas, basal cell carcinomas, colorectal, prostate and gastric cancers displayed moderate cytoplasmic positivity. Cancer cells in general were weakly stained or negative.
GENE INFORMATION
Gene name
FZD8
Synonyms
Description
Frizzled class receptor 8 (HGNC Symbol)
Entrez gene summary
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]