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CLDN22

GENERAL INFORMATION

Gene name

 CLDN22

Gene description

 Claudin 22

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

 Evidence at transcript level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CLDN22 (HGNC Symbol)

Synonyms

 CLDN21

Description

 Claudin 22 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. [provided by RefSeq, Aug 2010]

Chromosome

 4

Cytoband

 q35.1

Chromosome location (bp)

 183318194 - 183320774

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000177300 (version 83.38)

Entrez gene

 53842

UniProt

 Q8N7P3 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8N7P3

Antibodypedia

 CLDN22 antibodies

PROTEIN BROWSER
CLDN22-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLDN22-001
ENSP00000318113
ENST00000323319
Q8N7P3 [Direct mapping]
Claudin-22
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
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GO:0005198 [structural molecule activity]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0016021 [integral component of membrane]
GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules]
GO:0034329 [cell junction assembly]
GO:0042802 [identical protein binding]
GO:0045216 [cell-cell junction organization]
GO:0070830 [bicellular tight junction assembly]
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 220 aa
24.5 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.