Fields »
ABOUT
HELP
BLOG
KCNA2

GENERAL INFORMATION

Gene name

 KCNA2

Gene description

 Potassium channel, voltage gated shaker related subfamily A, member 2

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Cell line enhanced (Karpas-707, SCLC-21H, U-2 OS, U-266/70, U-266/84, WM-115)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in the CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Supported based on 1 antibody.
CAB001976
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
CAB001976

GENE INFORMATION

Gene name

 KCNA2 (HGNC Symbol)

Synonyms

 HK4, Kv1.2

Description

 Potassium channel, voltage gated shaker related subfamily A, member 2 (HGNC Symbol)

Entrez gene summary

 Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 110593580 - 110631474

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177301 (version 83.38)

Entrez gene

 3737

UniProt

 P16389 (UniProt - Evidence at protein level)

neXtProt

 NX_P16389

Antibodypedia

 KCNA2 antibodies

PROTEIN BROWSER
KCNA2-001
KCNA2-002
KCNA2-003
KCNA2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNA2-001
ENSP00000358785
ENST00000369770
P16389 [Direct mapping]
Potassium voltage-gated channel subfamily A member 2
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005267 [potassium channel activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0014059 [regulation of dopamine secretion]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0019233 [sensory perception of pain]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031258 [lamellipodium membrane]
GO:0032809 [neuronal cell body membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0043679 [axon terminus]
GO:0044224 [juxtaparanode region of axon]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 356 aa
41 kDa 		No 3
KCNA2-002
ENSP00000487785
ENST00000633222
P16389 [Direct mapping]
Potassium voltage-gated channel subfamily A member 2
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005267 [potassium channel activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0014059 [regulation of dopamine secretion]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0019233 [sensory perception of pain]
GO:0021633 [optic nerve structural organization]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031258 [lamellipodium membrane]
GO:0032809 [neuronal cell body membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0043679 [axon terminus]
GO:0044224 [juxtaparanode region of axon]
GO:0045188 [regulation of circadian sleep/wake cycle, non-REM sleep]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 499 aa
56.7 kDa 		No 6
KCNA2-003
ENSP00000314520
ENST00000316361
P16389 [Direct mapping]
Potassium voltage-gated channel subfamily A member 2
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005267 [potassium channel activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0014059 [regulation of dopamine secretion]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0019233 [sensory perception of pain]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031258 [lamellipodium membrane]
GO:0032809 [neuronal cell body membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0043679 [axon terminus]
GO:0044224 [juxtaparanode region of axon]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 499 aa
56.7 kDa 		No 6
KCNA2-006
ENSP00000433109
ENST00000485317
P16389 [Direct mapping]
Potassium voltage-gated channel subfamily A member 2
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005267 [potassium channel activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0014059 [regulation of dopamine secretion]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0019233 [sensory perception of pain]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031258 [lamellipodium membrane]
GO:0032809 [neuronal cell body membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042734 [presynaptic membrane]
GO:0043204 [perikaryon]
GO:0043679 [axon terminus]
GO:0044224 [juxtaparanode region of axon]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 499 aa
56.7 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.