Expression of BEND2 in cancer - Summary - The Human Protein Atlas

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BEND2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BEND2
Gene description	BEN domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct nuclear expression in subset of cells in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA009420 , HPA013142
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA009420	HPA013142

GENE INFORMATION
Gene name	BEND2 (HGNC Symbol)
Synonyms	CXorf20, MGC33653
Description	BEN domain containing 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which has two BEN domains in the C-terminus. These domains are found in proteins which participate in protein and DNA interactions which occur during chromatin restructuring or transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Chromosome	X
Cytoband	p22.13
Chromosome location (bp)	18162931 - 18220883
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177324 (version 83.38)
Entrez gene	139105
UniProt	Q8NDZ0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NDZ0
Antibodypedia	BEND2 antibodies

PROTEIN BROWSER

BEND2-001	BEND2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BEND2-001 ENSP00000369372 ENST00000380033	Q8NDZ0 [Direct mapping] BEN domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		799 aa 87.9 kDa	No	0
BEND2-201 ENSP00000369369 ENST00000380030	Q8NDZ0 [Direct mapping] BEN domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		645 aa 71.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.