Expression of CD19 in cancer - Summary - The Human Protein Atlas

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CD19

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD19
Gene description	CD19 molecule
Protein class	CD markers Disease related genes FDA approved drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (Daudi, REH, U-698)
HPA (normal tissue):	Group enriched (appendix, lymph node, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB016110
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB016110

GENE INFORMATION
Gene name	CD19
Synonyms
Description	CD19 molecule (HGNC Symbol)
Entrez gene summary	Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	28931939 - 28939346
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177455 (version 83.38)
Entrez gene	930
UniProt	P15391 (UniProt - Evidence at protein level)
neXtProt	NX_P15391
Antibodypedia	CD19 antibodies

PROTEIN BROWSER

CD19-001	CD19-004	CD19-201	CD19-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD19-001 ENSP00000313419 ENST00000324662	P15391 [Direct mapping] B-lymphocyte antigen CD19 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005057 [receptor signaling protein activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006968 [cellular defense response] GO:0007166 [cell surface receptor signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043234 [protein complex] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050776 [regulation of immune response] GO:0050853 [B cell receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	556 aa 61.1 kDa	Yes	2
CD19-004 ENSP00000456201 ENST00000567541	P15391 [Direct mapping] B-lymphocyte antigen CD19 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005057 [receptor signaling protein activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006968 [cellular defense response] GO:0007166 [cell surface receptor signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043234 [protein complex] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050776 [regulation of immune response] GO:0050853 [B cell receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	557 aa 61.2 kDa	Yes	2
CD19-201 ENSP00000437940 ENST00000538922	P15391 [Direct mapping] B-lymphocyte antigen CD19 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005057 [receptor signaling protein activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006968 [cellular defense response] GO:0007166 [cell surface receptor signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043234 [protein complex] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050776 [regulation of immune response] GO:0050853 [B cell receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	557 aa 61.2 kDa	Yes	2
CD19-202 ENSP00000481090 ENST00000611258	A0A087WXJ7 [Direct mapping] B-lymphocyte antigen CD19 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	467 aa 51.8 kDa	Yes	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.