Fields »
ABOUT
HELP
BLOG
ACOT4

GENERAL INFORMATION

Gene name

 ACOT4

Gene description

 Acyl-CoA thioesterase 4

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SK-BR-3, T-47d)
HPA (normal tissue):Tissue enhanced (kidney)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in selected tissues, strongest in liver.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Nucleolar staining observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA000779
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000779

GENE INFORMATION

Gene name

 ACOT4 (HGNC Symbol)

Synonyms

 FLJ31235, PTE-Ib, PTE2B

Description

 Acyl-CoA thioesterase 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 14

Cytoband

 q24.3

Chromosome location (bp)

 73591706 - 73596496

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177465 (version 83.38)

Entrez gene

 122970

UniProt

 Q8N9L9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N9L9

Antibodypedia

 ACOT4 antibodies

PROTEIN BROWSER
ACOT4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACOT4-001
ENSP00000323071
ENST00000326303
Q8N9L9 [Direct mapping]
Acyl-coenzyme A thioesterase 4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000038 [very long-chain fatty acid metabolic process]
GO:0001676 [long-chain fatty acid metabolic process]
GO:0004778 [succinyl-CoA hydrolase activity]
GO:0005102 [receptor binding]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0006104 [succinyl-CoA metabolic process]
GO:0006637 [acyl-CoA metabolic process]
GO:0016290 [palmitoyl-CoA hydrolase activity]
GO:0016790 [thiolester hydrolase activity]
GO:0019432 [triglyceride biosynthetic process]
GO:0032788 [saturated monocarboxylic acid metabolic process]
GO:0032789 [unsaturated monocarboxylic acid metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0043648 [dicarboxylic acid metabolic process]
GO:0043649 [dicarboxylic acid catabolic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046459 [short-chain fatty acid metabolic process]
GO:0047617 [acyl-CoA hydrolase activity]
GO:0052689 [carboxylic ester hydrolase activity]
Show all
 421 aa
46.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.