Fields »
ABOUT
HELP
BLOG
PTRF

GENERAL INFORMATION

Gene name

 PTRF

Gene description

 Polymerase I and transcript release factor

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ, U-138 MG)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression mainly in blood vessels and adipocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
HPA049838
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable), ovarian cancer (unfavourable) and colorectal cancer (unfavourable).
Urothelial cancer p<0.001
Ovarian cancer p<0.001
Colorectal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049838

GENE INFORMATION

Gene name

 PTRF (HGNC Symbol)

Synonyms

 cavin-1, CAVIN1

Description

 Polymerase I and transcript release factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 42402452 - 42423517

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177469 (version 83.38)

Entrez gene

 284119

UniProt

 Q6NZI2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6NZI2

Antibodypedia

 PTRF antibodies

PROTEIN BROWSER
PTRF-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTRF-001
ENSP00000349541
ENST00000357037
Q6NZI2 [Direct mapping]
Polymerase I and transcript release factor
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0010467 [gene expression]
GO:0042134 [rRNA primary transcript binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0044822 [poly(A) RNA binding]
GO:0045121 [membrane raft]
Show all
 390 aa
43.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.