Tissue expression of TBL1XR1 - Summary - The Human Protein Atlas

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TBL1XR1

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TBL1XR1
Gene description	Transducin (beta)-like 1 X-linked receptor 1
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	18
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General nuclear expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA019182
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TBL1XR1 (HGNC Symbol)
Synonyms	C21, DC42, FLJ12894, IRA1, TBLR1
Description	Transducin (beta)-like 1 X-linked receptor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q26.32
Chromosome location (bp)	177019355 - 177197396
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177565 (version 83.38)
Entrez gene	79718
UniProt	Q9BZK7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZK7
Antibodypedia	TBL1XR1 antibodies

PROTEIN BROWSER

TBL1XR1-001	TBL1XR1-002	TBL1XR1-003	TBL1XR1-005	TBL1XR1-006	TBL1XR1-007	TBL1XR1-008	TBL1XR1-009	TBL1XR1-010	TBL1XR1-011	TBL1XR1-012	TBL1XR1-013	TBL1XR1-014	TBL1XR1-017	TBL1XR1-019	TBL1XR1-020	TBL1XR1-022	TBL1XR1-023

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBL1XR1-001 ENSP00000405574 ENST00000430069	Q9BZK7 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002021 [response to dietary excess] GO:0003677 [DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005876 [spindle microtubule] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0007219 [Notch signaling pathway] GO:0008013 [beta-catenin binding] GO:0010468 [regulation of gene expression] GO:0016042 [lipid catabolic process] GO:0016575 [histone deacetylation] GO:0017053 [transcriptional repressor complex] GO:0030814 [regulation of cAMP metabolic process] GO:0035264 [multicellular organism growth] GO:0042393 [histone binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0050872 [white fat cell differentiation] GO:0060070 [canonical Wnt signaling pathway] GO:0060612 [adipose tissue development] GO:0060613 [fat pad development] GO:0090207 [regulation of triglyceride metabolic process] Show all	514 aa 55.6 kDa	No	0
TBL1XR1-002 ENSP00000413251 ENST00000457928	Q9BZK7 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005876 [spindle microtubule] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0007219 [Notch signaling pathway] GO:0008013 [beta-catenin binding] GO:0016575 [histone deacetylation] GO:0017053 [transcriptional repressor complex] GO:0042393 [histone binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0060070 [canonical Wnt signaling pathway] Show all	514 aa 55.6 kDa	No	0
TBL1XR1-003 ENSP00000263964 ENST00000352800	F8W9D8 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016575 [histone deacetylation] Show all	144 aa 15.2 kDa	No	0
TBL1XR1-005 ENSP00000387849 ENST00000422442	C9JY82 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016575 [histone deacetylation] Show all	72 aa 7.8 kDa	No	0
TBL1XR1-006 ENSP00000401044 ENST00000427349	C9JTW8 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016575 [histone deacetylation] Show all	62 aa 6.8 kDa	No	0
TBL1XR1-007 ENSP00000391559 ENST00000428970	C9JBN1 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016575 [histone deacetylation] Show all	76 aa 7.9 kDa	No	0
TBL1XR1-008 ENSP00000396120 ENST00000443315	C9JEC9 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016575 [histone deacetylation] Show all	81 aa 8.8 kDa	No	0
TBL1XR1-009 ENSP00000404863 ENST00000424913	C9JCK0 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016575 [histone deacetylation] Show all	73 aa 7.6 kDa	No	0
TBL1XR1-010 ENSP00000392180 ENST00000437738	C9IYU9 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016575 [histone deacetylation] Show all	145 aa 15.3 kDa	No	0
TBL1XR1-011 ENSP00000398477 ENST00000422066	C9J3H2 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016575 [histone deacetylation] Show all	87 aa 9.4 kDa	No	0
TBL1XR1-012 ENSP00000397450 ENST00000431674	C9J903 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016575 [histone deacetylation] Show all	96 aa 10.5 kDa	No	0
TBL1XR1-013 ENSP00000415506 ENST00000413084	C9JCW4 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016575 [histone deacetylation] Show all	33 aa 3.8 kDa	No	0
TBL1XR1-014 ENSP00000402402 ENST00000431421	C9JLJ1 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016575 [histone deacetylation] Show all	55 aa 5.6 kDa	No	0
TBL1XR1-017 ENSP00000406297 ENST00000450267	C9J7E1 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016575 [histone deacetylation] Show all	120 aa 12.8 kDa	No	0
TBL1XR1-019 ENSP00000486235 ENST00000630796	A0A0D9SF25 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016575 [histone deacetylation] Show all	122 aa 13 kDa	No	0
TBL1XR1-020 ENSP00000486866 ENST00000626672	A0A0D9SFS8 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016575 [histone deacetylation] Show all	112 aa 12.2 kDa	No	0
TBL1XR1-022 ENSP00000486082 ENST00000630833	A0A0D9SEW5 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016575 [histone deacetylation] Show all	105 aa 11.6 kDa	No	0
TBL1XR1-023 ENSP00000486622 ENST00000626758	A0A0D9SFI2 [Direct mapping] F-box-like/WD repeat-containing protein TBL1XR1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016575 [histone deacetylation] Show all	67 aa 6.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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