Moderate to strong nuclear immunoreactivity was observed in squamous cell carcinomas. Most other tumors were negative.
JUN (HGNC Symbol)
Jun proto-oncogene (HGNC Symbol)
Entrez gene summary
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
GO:0000228 [nuclear chromosome] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding] GO:0001525 [angiogenesis] GO:0001774 [microglial cell activation] GO:0001836 [release of cytochrome c from mitochondria] GO:0001889 [liver development] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003151 [outflow tract morphogenesis] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003713 [transcription coactivator activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005719 [nuclear euchromatin] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007184 [SMAD protein import into nucleus] GO:0007568 [aging] GO:0007612 [learning] GO:0007623 [circadian rhythm] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009314 [response to radiation] GO:0009612 [response to mechanical stimulus] GO:0009987 [cellular process] GO:0010033 [response to organic substance] GO:0010634 [positive regulation of epithelial cell migration] GO:0010941 [regulation of cell death] GO:0014070 [response to organic cyclic compound] GO:0017053 [transcriptional repressor complex] GO:0019899 [enzyme binding] GO:0030224 [monocyte differentiation] GO:0031103 [axon regeneration] GO:0031953 [negative regulation of protein autophosphorylation] GO:0032496 [response to lipopolysaccharide] GO:0032870 [cellular response to hormone stimulus] GO:0033613 [activating transcription factor binding] GO:0034097 [response to cytokine] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035026 [leading edge cell differentiation] GO:0035497 [cAMP response element binding] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035994 [response to muscle stretch] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043392 [negative regulation of DNA binding] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0043547 [positive regulation of GTPase activity] GO:0043565 [sequence-specific DNA binding] GO:0043922 [negative regulation by host of viral transcription] GO:0043923 [positive regulation by host of viral transcription] GO:0044212 [transcription regulatory region DNA binding] GO:0044822 [poly(A) RNA binding] GO:0045087 [innate immune response] GO:0045597 [positive regulation of cell differentiation] GO:0045657 [positive regulation of monocyte differentiation] GO:0045740 [positive regulation of DNA replication] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0051365 [cellular response to potassium ion starvation] GO:0051403 [stress-activated MAPK cascade] GO:0051591 [response to cAMP] GO:0051726 [regulation of cell cycle] GO:0051899 [membrane depolarization] GO:0060395 [SMAD protein signal transduction] GO:0061029 [eyelid development in camera-type eye] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070412 [R-SMAD binding] GO:0071277 [cellular response to calcium ion] GO:0071837 [HMG box domain binding] GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter] GO:1990441 [negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:2000144 [positive regulation of DNA-templated transcription, initiation]