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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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JUN
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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

JUN

Gene description

Jun proto-oncogene

Protein class

Cancer-related genes
FDA approved drug targets
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (RH-30)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues, mostly in a fraction of the cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
CAB003801 , CAB007780
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

CAB003801
CAB007780

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant cells showed distinct nuclear immunoreactivity of varying fraction and intensity. Several malignant lymphomas, testicular cancers and liver cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong nuclear immunoreactivity was observed in squamous cell carcinomas. Most other tumors were negative.

GENE INFORMATION

Gene name

JUN (HGNC Symbol)

Synonyms

AP-1, c-Jun

Description

Jun proto-oncogene (HGNC Symbol)

Entrez gene summary

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p32.1

Chromosome location (bp)

58780788 - 58784327

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000177606 (version 83.38)

Entrez gene

3725

UniProt

P05412 (UniProt - Evidence at protein level)

neXtProt

NX_P05412

Antibodypedia

JUN antibodies

PROTEIN BROWSER

JUN-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

JUN-001
ENSP00000360266
ENST00000371222
P05412 [Direct mapping]
Transcription factor AP-1
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Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000228 [nuclear chromosome]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0001525 [angiogenesis]
GO:0001774 [microglial cell activation]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0001889 [liver development]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003151 [outflow tract morphogenesis]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003713 [transcription coactivator activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005719 [nuclear euchromatin]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007184 [SMAD protein import into nucleus]
GO:0007568 [aging]
GO:0007612 [learning]
GO:0007623 [circadian rhythm]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009314 [response to radiation]
GO:0009612 [response to mechanical stimulus]
GO:0009987 [cellular process]
GO:0010033 [response to organic substance]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010941 [regulation of cell death]
GO:0014070 [response to organic cyclic compound]
GO:0017053 [transcriptional repressor complex]
GO:0019899 [enzyme binding]
GO:0030224 [monocyte differentiation]
GO:0031103 [axon regeneration]
GO:0031953 [negative regulation of protein autophosphorylation]
GO:0032496 [response to lipopolysaccharide]
GO:0032870 [cellular response to hormone stimulus]
GO:0033613 [activating transcription factor binding]
GO:0034097 [response to cytokine]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035026 [leading edge cell differentiation]
GO:0035497 [cAMP response element binding]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035994 [response to muscle stretch]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0043565 [sequence-specific DNA binding]
GO:0043922 [negative regulation by host of viral transcription]
GO:0043923 [positive regulation by host of viral transcription]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045597 [positive regulation of cell differentiation]
GO:0045657 [positive regulation of monocyte differentiation]
GO:0045740 [positive regulation of DNA replication]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051365 [cellular response to potassium ion starvation]
GO:0051403 [stress-activated MAPK cascade]
GO:0051591 [response to cAMP]
GO:0051726 [regulation of cell cycle]
GO:0051899 [membrane depolarization]
GO:0060395 [SMAD protein signal transduction]
GO:0061029 [eyelid development in camera-type eye]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070412 [R-SMAD binding]
GO:0071277 [cellular response to calcium ion]
GO:0071837 [HMG box domain binding]
GO:1902895 [positive regulation of pri-miRNA transcription from RNA polymerase II promoter]
GO:1990441 [negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000144 [positive regulation of DNA-templated transcription, initiation]
Show all
331 aa
35.7 kDa
No 0

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