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IL17RA

GENERAL INFORMATION

Gene name

 IL17RA

Gene description

 Interleukin 17 receptor A

Protein class

 CD markers
Disease related genes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Distinct cytoplasmic expression in immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 1 antibody.
CAB024996
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IL17RA (HGNC Symbol)

Synonyms

 CD217, CDw217, hIL-17R, IL-17RA, IL17R

Description

 Interleukin 17 receptor A (HGNC Symbol)

Entrez gene summary

 Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

Chromosome

 22

Cytoband

 q11.1

Chromosome location (bp)

 17084954 - 17115694

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177663 (version 83.38)

Entrez gene

 23765

UniProt

 Q96F46 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96F46

Antibodypedia

 IL17RA antibodies

PROTEIN BROWSER
IL17RA-001
IL17RA-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL17RA-001
ENSP00000320936
ENST00000319363
Q96F46 [Direct mapping]
Interleukin-17 receptor A
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030368 [interleukin-17 receptor activity]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0050729 [positive regulation of inflammatory response]
GO:0050832 [defense response to fungus]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071621 [granulocyte chemotaxis]
GO:0072537 [fibroblast activation]
GO:1900017 [positive regulation of cytokine production involved in inflammatory response]
GO:2000664 [positive regulation of interleukin-5 secretion]
GO:2000667 [positive regulation of interleukin-13 secretion]
Show all
 866 aa
96.1 kDa 		Yes 1
IL17RA-201
ENSP00000479970
ENST00000612619
Q96F46 [Direct mapping]
Interleukin-17 receptor A
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CD markers
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030368 [interleukin-17 receptor activity]
GO:0032747 [positive regulation of interleukin-23 production]
GO:0072537 [fibroblast activation]
Show all
 832 aa
92.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.