Expression of CD163L1 in cancer - Summary - The Human Protein Atlas

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CD163L1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD163L1
Gene description	CD163 molecule-like 1
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (U-87 MG)
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High cytoplasmic expression in a subset of lymphoid cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA015663
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015663

GENE INFORMATION
Gene name	CD163L1 (HGNC Symbol)
Synonyms	CD163B, M160
Description	CD163 molecule-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	7346685 - 7479897
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177675 (version 83.38)
Entrez gene	283316
UniProt	Q9NR16 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NR16
Antibodypedia	CD163L1 antibodies

PROTEIN BROWSER

CD163L1-001	CD163L1-002	CD163L1-003	CD163L1-006	CD163L1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD163L1-001 ENSP00000315945 ENST00000313599	Q9NR16 [Direct mapping] Scavenger receptor cysteine-rich type 1 protein M160 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0005044 [scavenger receptor activity] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	1453 aa 159.2 kDa	No	1
CD163L1-002 ENSP00000393474 ENST00000416109	Q9NR16 [Direct mapping] Scavenger receptor cysteine-rich type 1 protein M160 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0005044 [scavenger receptor activity] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	1463 aa 160.3 kDa	No	1
CD163L1-003 ENSP00000439921 ENST00000545926	H0YFR4 [Direct mapping] Scavenger receptor cysteine-rich type 1 protein M160 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	189 aa 20.8 kDa	No	0
CD163L1-006 ENSP00000438217 ENST00000539726	H0YFE6 [Direct mapping] Scavenger receptor cysteine-rich type 1 protein M160 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	109 aa 11.9 kDa	No	1
CD163L1-010 ENSP00000442328 ENST00000543276	F5H7R7 [Direct mapping] Scavenger receptor cysteine-rich type 1 protein M160 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	62 aa 7.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.