Fields »
ABOUT
HELP
BLOG
SOX12

GENERAL INFORMATION

Gene name

 SOX12

Gene description

 SRY (sex determining region Y)-box 12

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SOX12 (HGNC Symbol)

Synonyms

 SOX22

Description

 SRY (sex determining region Y)-box 12 (HGNC Symbol)

Entrez gene summary

 Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 325401 - 330224

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177732 (version 83.38)

Entrez gene

 6666

UniProt

 O15370 (UniProt - Evidence at transcript level)

neXtProt

 NX_O15370

Antibodypedia

 SOX12 antibodies

PROTEIN BROWSER
SOX12-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOX12-001
ENSP00000347646
ENST00000342665
O15370 [Direct mapping]
Transcription factor SOX-12
Show all
Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003677 [DNA binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0021510 [spinal cord development]
GO:0032993 [protein-DNA complex]
GO:0045165 [cell fate commitment]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0065004 [protein-DNA complex assembly]
Show all
 315 aa
34.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.