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KCNJ10

GENERAL INFORMATION

Gene name

 KCNJ10

Gene description

 Potassium channel, inwardly rectifying subfamily J, member 10

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (Hep G2, RH-30, SK-MEL-30, U-266/70)
HPA (normal tissue):Group enriched (cerebral cortex, kidney)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 KCNJ10 (HGNC Symbol)

Synonyms

 Kir1.2, Kir4.1

Description

 Potassium channel, inwardly rectifying subfamily J, member 10 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q23.2

Chromosome location (bp)

 160037467 - 160070248

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177807 (version 83.38)

Entrez gene

 3766

UniProt

 P78508 (UniProt - Evidence at protein level)

neXtProt

 NX_P78508

Antibodypedia

 KCNJ10 antibodies

PROTEIN BROWSER
KCNJ10-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNJ10-001
ENSP00000357068
ENST00000368089
P78508 [Direct mapping]
ATP-sensitive inward rectifier potassium channel 10
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Voltage-gated ion channels
   Inwardly Rectifying Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0005242 [inward rectifier potassium channel activity]
GO:0005267 [potassium channel activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006813 [potassium ion transport]
GO:0007268 [synaptic transmission]
GO:0007601 [visual perception]
GO:0007628 [adult walking behavior]
GO:0010107 [potassium ion import]
GO:0014003 [oligodendrocyte development]
GO:0015272 [ATP-activated inward rectifier potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0022010 [central nervous system myelination]
GO:0034765 [regulation of ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0051935 [glutamate reuptake]
GO:0055075 [potassium ion homeostasis]
GO:0060075 [regulation of resting membrane potential]
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 379 aa
42.5 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.