Expression of CHID1 in cancer - Summary - The Human Protein Atlas

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CHID1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CHID1
Gene description	Chitinase domain containing 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA039374
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039374

GENE INFORMATION
Gene name	CHID1 (HGNC Symbol)
Synonyms	FLJ42707, MGC3234
Description	Chitinase domain containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	867860 - 915058
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177830 (version 83.38)
Entrez gene	66005
UniProt	Q9BWS9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BWS9
Antibodypedia	CHID1 antibodies

PROTEIN BROWSER

CHID1-001	CHID1-002	CHID1-003	CHID1-004	CHID1-005	CHID1-006	CHID1-007	CHID1-008	CHID1-009	CHID1-011	CHID1-015	CHID1-024	CHID1-201	CHID1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHID1-001 ENSP00000325055 ENST00000323578	Q9BWS9 [Direct mapping] Chitinase domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005802 [trans-Golgi network] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] GO:0016020 [membrane] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070492 [oligosaccharide binding] GO:1900016 [negative regulation of cytokine production involved in inflammatory response] Show all	393 aa 44.9 kDa	Yes	0
CHID1-002 ENSP00000435503 ENST00000528581	Q9BWS9 [Direct mapping] Chitinase domain-containing protein 1 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005802 [trans-Golgi network] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] GO:0016020 [membrane] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070492 [oligosaccharide binding] GO:1900016 [negative regulation of cytokine production involved in inflammatory response] Show all	418 aa 47.6 kDa	Yes	0
CHID1-003 ENSP00000416034 ENST00000429789	Q9BWS9 [Direct mapping] Chitinase domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005802 [trans-Golgi network] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] GO:0016020 [membrane] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070492 [oligosaccharide binding] GO:1900016 [negative regulation of cytokine production involved in inflammatory response] Show all	362 aa 41.7 kDa	Yes	0
CHID1-004 ENSP00000388156 ENST00000436108	Q9BWS9 [Direct mapping] Chitinase domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005802 [trans-Golgi network] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] GO:0016020 [membrane] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070492 [oligosaccharide binding] GO:1900016 [negative regulation of cytokine production involved in inflammatory response] Show all	393 aa 44.9 kDa	Yes	0
CHID1-005 ENSP00000436017 ENST00000533056	E9PRL3 [Direct mapping] Chitinase domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	132 aa 14.9 kDa	Yes	0
CHID1-006 ENSP00000435731 ENST00000533059	E9PIP0 [Direct mapping] Chitinase domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	119 aa 13.4 kDa	Yes	0
CHID1-007 ENSP00000431766 ENST00000528154	E9PJL0 [Direct mapping] Chitinase domain-containing protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	26 aa 2.9 kDa	Yes	0
CHID1-008 ENSP00000435607 ENST00000525840	E9PJ91 [Direct mapping] Chitinase domain-containing protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	38 aa 4.2 kDa	Yes	0
CHID1-009 ENSP00000436752 ENST00000530939	E9PI70 [Direct mapping] Chitinase domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	116 aa 13.1 kDa	Yes	0
CHID1-011 ENSP00000433570 ENST00000525225	E9PKF1 [Direct mapping] Chitinase domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	84 aa 9.3 kDa	Yes	0
CHID1-015 ENSP00000434651 ENST00000531859	E9PPA0 [Direct mapping] Chitinase domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	224 aa 25.1 kDa	Yes	0
CHID1-024 ENSP00000431169 ENST00000529539	H0YC89 [Direct mapping] Chitinase domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004568 [chitinase activity] GO:0005576 [extracellular region] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] Show all	108 aa 12.5 kDa	No	0
CHID1-201 ENSP00000391255 ENST00000449825	Q9BWS9 [Direct mapping] Chitinase domain-containing protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005802 [trans-Golgi network] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] GO:0016020 [membrane] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070492 [oligosaccharide binding] GO:1900016 [negative regulation of cytokine production involved in inflammatory response] Show all	393 aa 44.9 kDa	Yes	0
CHID1-202 ENSP00000398722 ENST00000454838	Q9BWS9 [Direct mapping] Chitinase domain-containing protein 1 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004568 [chitinase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005764 [lysosome] GO:0005770 [late endosome] GO:0005802 [trans-Golgi network] GO:0005975 [carbohydrate metabolic process] GO:0006032 [chitin catabolic process] GO:0008061 [chitin binding] GO:0016020 [membrane] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0070492 [oligosaccharide binding] GO:1900016 [negative regulation of cytokine production involved in inflammatory response] Show all	418 aa 47.6 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.