Expression of SVBP in cancer - Summary - The Human Protein Atlas

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SVBP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SVBP
Gene description	Small vasohibin binding protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in smooth muscle cells and squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA008507
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and breast cancer (favourable).
Liver cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008507

GENE INFORMATION
Gene name	SVBP (HGNC Symbol)
Synonyms	CCDC23, MGC45441
Description	Small vasohibin binding protein (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	42807052 - 42817252
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177868 (version 83.38)
Entrez gene	374969
UniProt	Q8N300 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N300
Antibodypedia	SVBP antibodies

PROTEIN BROWSER

SVBP-001	SVBP-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SVBP-001 ENSP00000361599 ENST00000372521	Q8N300 [Direct mapping] Small vasohibin-binding protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0009306 [protein secretion] GO:0010596 [negative regulation of endothelial cell migration] GO:0031397 [negative regulation of protein ubiquitination] GO:0045177 [apical part of cell] Show all	66 aa 7.8 kDa	No	0
SVBP-002 ENSP00000361600 ENST00000372522	Q8N300 [Direct mapping] Small vasohibin-binding protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0009306 [protein secretion] GO:0010596 [negative regulation of endothelial cell migration] GO:0031397 [negative regulation of protein ubiquitination] GO:0045177 [apical part of cell] Show all	66 aa 7.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.