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GRB2

GENERAL INFORMATION

Gene name

 GRB2

Gene description

 Growth factor receptor-bound protein 2

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in most tissues, including lymphoid tissue and CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB002589
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GRB2 (HGNC Symbol)

Synonyms

 NCKAP2

Description

 Growth factor receptor-bound protein 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 75318076 - 75405709

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177885 (version 83.38)

Entrez gene

 2885

UniProt

 P62993 (UniProt - Evidence at protein level)

neXtProt

 NX_P62993

Antibodypedia

 GRB2 antibodies

PROTEIN BROWSER
GRB2-001
GRB2-002
GRB2-003
GRB2-004
GRB2-007
GRB2-008
GRB2-009
GRB2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRB2-001
ENSP00000339007
ENST00000316804
P62993 [Direct mapping]
Growth factor receptor-bound protein 2
B0LPF3 [Target identity:100%; Query identity:100%]
Growth factor receptor-bound protein 2; Growth factor receptor-bound protein 2, isoform CRA_a; cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0031295 [T cell costimulation]
GO:0031623 [receptor internalization]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0043560 [insulin receptor substrate binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070436 [Grb2-EGFR complex]
GO:0071479 [cellular response to ionizing radiation]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 217 aa
25.2 kDa 		No 0
GRB2-002
ENSP00000376345
ENST00000392562
P62993 [Direct mapping]
Growth factor receptor-bound protein 2
B0LPF3 [Target identity:100%; Query identity:100%]
Growth factor receptor-bound protein 2; Growth factor receptor-bound protein 2, isoform CRA_a; cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0012506 [vesicle membrane]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0019904 [protein domain specific binding]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031295 [T cell costimulation]
GO:0031623 [receptor internalization]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0043408 [regulation of MAPK cascade]
GO:0043560 [insulin receptor substrate binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0050900 [leukocyte migration]
GO:0060670 [branching involved in labyrinthine layer morphogenesis]
GO:0070062 [extracellular exosome]
GO:0070436 [Grb2-EGFR complex]
GO:0071479 [cellular response to ionizing radiation]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 217 aa
25.2 kDa 		No 0
GRB2-003
ENSP00000376347
ENST00000392564
P62993 [Direct mapping]
Growth factor receptor-bound protein 2
B0LPF3 [Target identity:100%; Query identity:100%]
Growth factor receptor-bound protein 2; Growth factor receptor-bound protein 2, isoform CRA_a; cDNA, FLJ96637, Homo sapiens growth factor receptor-bound protein 2 (GRB2), mRNA
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0031295 [T cell costimulation]
GO:0031623 [receptor internalization]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0043560 [insulin receptor substrate binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070436 [Grb2-EGFR complex]
GO:0071479 [cellular response to ionizing radiation]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 217 aa
25.2 kDa 		No 0
GRB2-004
ENSP00000376346
ENST00000392563
P62993 [Direct mapping]
Growth factor receptor-bound protein 2
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0031295 [T cell costimulation]
GO:0031623 [receptor internalization]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0043560 [insulin receptor substrate binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070436 [Grb2-EGFR complex]
GO:0071479 [cellular response to ionizing radiation]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 176 aa
20.6 kDa 		No 0
GRB2-007
ENSP00000462785
ENST00000582582
J3KT38 [Direct mapping]
Growth factor receptor-bound protein 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 111 aa
12.8 kDa 		No 0
GRB2-008
ENSP00000464279
ENST00000578961
J3QRL5 [Direct mapping]
Growth factor receptor-bound protein 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 156 aa
17.6 kDa 		No 0
GRB2-009
ENSP00000463525
ENST00000581959
J3QLF6 [Direct mapping]
Growth factor receptor-bound protein 2
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 42 aa
4.7 kDa 		No 0
GRB2-201
ENSP00000317360
ENST00000316615
P62993 [Direct mapping]
Growth factor receptor-bound protein 2
Show all
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008180 [COP9 signalosome]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016032 [viral process]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030168 [platelet activation]
GO:0031295 [T cell costimulation]
GO:0031623 [receptor internalization]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042770 [signal transduction in response to DNA damage]
GO:0042802 [identical protein binding]
GO:0043560 [insulin receptor substrate binding]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050900 [leukocyte migration]
GO:0070062 [extracellular exosome]
GO:0070436 [Grb2-EGFR complex]
GO:0071479 [cellular response to ionizing radiation]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
 176 aa
20.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.