Expression of ARL6IP6 in cancer - Summary - The Human Protein Atlas

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ARL6IP6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ARL6IP6
Gene description	ADP-ribosylation factor-like 6 interacting protein 6
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA014743
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA014743

GENE INFORMATION
Gene name	ARL6IP6 (HGNC Symbol)
Synonyms	MGC33864
Description	ADP-ribosylation factor-like 6 interacting protein 6 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q23.3
Chromosome location (bp)	152717893 - 152761253
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177917 (version 83.38)
Entrez gene	151188
UniProt	Q8N6S5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N6S5
Antibodypedia	ARL6IP6 antibodies

PROTEIN BROWSER

ARL6IP6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARL6IP6-001 ENSP00000315357 ENST00000326446	Q8N6S5 [Direct mapping] ADP-ribosylation factor-like protein 6-interacting protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	226 aa 24.7 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.