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CAPZA3

GENERAL INFORMATION

Gene name

 CAPZA3

Gene description

 Capping protein (actin filament) muscle Z-line, alpha 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in spermatozoa.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA038688
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038688

GENE INFORMATION

Gene name

 CAPZA3 (HGNC Symbol)

Synonyms

 CAPPA3, Gsg3

Description

 Capping protein (actin filament) muscle Z-line, alpha 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta subunits. This protein may be important in determining sperm architecture and male fertility. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p12.3

Chromosome location (bp)

 18738101 - 18739187

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000177938 (version 83.38)

Entrez gene

 93661

UniProt

 Q96KX2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96KX2

Antibodypedia

 CAPZA3 antibodies

PROTEIN BROWSER
CAPZA3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAPZA3-001
ENSP00000326238
ENST00000317658
Q96KX2 [Direct mapping]
F-actin-capping protein subunit alpha-3
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Predicted intracellular proteins
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GO:0001669 [acrosomal vesicle]
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007286 [spermatid development]
GO:0008290 [F-actin capping protein complex]
GO:0016020 [membrane]
GO:0030863 [cortical cytoskeleton]
GO:0051016 [barbed-end actin filament capping]
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 299 aa
35 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.