Cell atlas - IMP3 - The Human Protein Atlas

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IMP3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	IMP3
Gene description	IMP3, U3 small nucleolar ribonucleoprotein
Protein class	Plasma proteins Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated), Nucleoli (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA060955 , HPA061177
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nucleoli.

Main location

Nucleus (validated), Nucleoli (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA060955	HEK 293	Nucleus
HPA060955	HEK 293	Nucleoli
HPA060955	U-2 OS	No staining
HPA061177	HEK 293	Nucleus
HPA061177	HEK 293	Nucleoli	Intensity
HPA061177	PC-3	Nucleus
HPA061177	PC-3	Nucleoli
HPA061177	U-2 OS	No staining

GENE INFORMATION
Gene name	IMP3 (HGNC Symbol)
Synonyms	BRMS2, C15orf12, FLJ10968, MRPS4
Description	IMP3, U3 small nucleolar ribonucleoprotein (HGNC Symbol)
Entrez gene summary	This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q24.2
Chromosome location (bp)	75639085 - 75648706
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177971 (version 83.38)
Entrez gene	55272
UniProt	Q9NV31 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NV31
Antibodypedia	IMP3 antibodies

PROTEIN BROWSER

IMP3-001	IMP3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IMP3-001 ENSP00000326981 ENST00000314852	Q9NV31 [Direct mapping] U3 small nucleolar ribonucleoprotein protein IMP3 Show all	Ribosomal proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0030515 [snoRNA binding] GO:0032040 [small-subunit processome] GO:0034457 [Mpp10 complex] GO:0044822 [poly(A) RNA binding] Show all	184 aa 21.8 kDa	No	0
IMP3-201 ENSP00000385217 ENST00000403490	Q9NV31 [Direct mapping] U3 small nucleolar ribonucleoprotein protein IMP3 Show all	Ribosomal proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0030515 [snoRNA binding] GO:0032040 [small-subunit processome] GO:0034457 [Mpp10 complex] GO:0044822 [poly(A) RNA binding] Show all	184 aa 21.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.