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DMAP1

GENERAL INFORMATION

Gene name

 DMAP1

Gene description

 DNA methyltransferase 1 associated protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
CAB033018
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB033018

GENE INFORMATION

Gene name

 DMAP1 (HGNC Symbol)

Synonyms

 DNMAP1, DNMTAP1, EAF2, FLJ11543, KIAA1425, MEAF2, SWC4

Description

 DNA methyltransferase 1 associated protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p34.1

Chromosome location (bp)

 44213455 - 44220681

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178028 (version 83.38)

Entrez gene

 55929

UniProt

 Q9NPF5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPF5

Antibodypedia

 DMAP1 antibodies

PROTEIN BROWSER
DMAP1-001
DMAP1-002
DMAP1-003
DMAP1-005
DMAP1-006
DMAP1-007
DMAP1-008
DMAP1-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DMAP1-001
ENSP00000354697
ENST00000361745
Q9NPF5 [Direct mapping]
DNA methyltransferase 1-associated protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006306 [DNA methylation]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
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 467 aa
53 kDa 		No 0
DMAP1-002
ENSP00000312697
ENST00000315913
Q9NPF5 [Direct mapping]
DNA methyltransferase 1-associated protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006306 [DNA methylation]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 467 aa
53 kDa 		No 0
DMAP1-003
ENSP00000361363
ENST00000372289
Q9NPF5 [Direct mapping]
DNA methyltransferase 1-associated protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006306 [DNA methylation]
GO:0006325 [chromatin organization]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0040008 [regulation of growth]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0045471 [response to ethanol]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 467 aa
53 kDa 		No 0
DMAP1-005
ENSP00000409200
ENST00000446292
Q5TG40 [Direct mapping]
DNA methyltransferase 1-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0006281 [DNA repair]
GO:0006338 [chromatin remodeling]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 302 aa
35.4 kDa 		No 0
DMAP1-006
ENSP00000401099
ENST00000440641
Q5TG38 [Direct mapping]
DNA methyltransferase 1-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006281 [DNA repair]
GO:0006338 [chromatin remodeling]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
Show all
 237 aa
27.7 kDa 		No 0
DMAP1-007
ENSP00000400269
ENST00000436069
Q5TG36 [Direct mapping]
DNA methyltransferase 1-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006281 [DNA repair]
GO:0006338 [chromatin remodeling]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
Show all
 151 aa
16.8 kDa 		No 0
DMAP1-008
ENSP00000402494
ENST00000437511
Q5TG39 [Direct mapping]
DNA methyltransferase 1-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006281 [DNA repair]
GO:0006338 [chromatin remodeling]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
Show all
 285 aa
33.1 kDa 		No 0
DMAP1-013
ENSP00000361364
ENST00000372290
Q5TG37 [Direct mapping]
DNA methyltransferase 1-associated protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006281 [DNA repair]
GO:0006338 [chromatin remodeling]
GO:0035267 [NuA4 histone acetyltransferase complex]
GO:0043967 [histone H4 acetylation]
GO:0043968 [histone H2A acetylation]
Show all
 132 aa
15.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.