Expression of ADAMTSL1 in cancer - Summary - The Human Protein Atlas

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ADAMTSL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAMTSL1
Gene description	ADAMTS-like 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (ASC TERT1, TIME, U-138 MG)
HPA (normal tissue):	Tissue enhanced (endometrium)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including endometrium.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA057437
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057437

GENE INFORMATION
Gene name	ADAMTSL1 (HGNC Symbol)
Synonyms	ADAMTSR1, C9orf94, FLJ35283
Description	ADAMTS-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband
Chromosome location (bp)	18473894 - 18910950
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178031 (version 83.38)
Entrez gene	92949
UniProt	Q8N6G6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N6G6
Antibodypedia	ADAMTSL1 antibodies

PROTEIN BROWSER

ADAMTSL1-001	ADAMTSL1-002	ADAMTSL1-003	ADAMTSL1-004	ADAMTSL1-005	ADAMTSL1-011	ADAMTSL1-012	ADAMTSL1-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTSL1-001 ENSP00000327887 ENST00000327883	Q8N6G6 [Direct mapping] ADAMTS-like protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] GO:0036066 [protein O-linked fucosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	525 aa 58.4 kDa	Yes	0
ADAMTSL1-002 ENSP00000369940 ENST00000380566	Q8N6G6 [Direct mapping] ADAMTS-like protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] GO:0036066 [protein O-linked fucosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	439 aa 48.8 kDa	Yes	0
ADAMTSL1-003 ENSP00000369944 ENST00000380570	A6NIB9 [Direct mapping] ADAMTS-like protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	219 aa 24.1 kDa	Yes	0
ADAMTSL1-004 ENSP00000401157 ENST00000431052	F8WEP3 [Direct mapping] ADAMTS-like protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	185 aa 20.5 kDa	Yes	0
ADAMTSL1-005 ENSP00000276935 ENST00000276935	Q8N6G6 [Direct mapping] ADAMTS-like protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] GO:0036066 [protein O-linked fucosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	683 aa 75.5 kDa	Yes	0
ADAMTSL1-011 ENSP00000369918 ENST00000380545	Q8N6G6 [Direct mapping] ADAMTS-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0036066 [protein O-linked fucosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	463 aa 50.6 kDa	Yes	0
ADAMTSL1-012 ENSP00000369921 ENST00000380548	Q8N6G6 [Direct mapping] ADAMTS-like protein 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005788 [endoplasmic reticulum lumen] GO:0006493 [protein O-linked glycosylation] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0036066 [protein O-linked fucosylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	1762 aa 193.4 kDa	Yes	0
ADAMTSL1-014 ENSP00000369911 ENST00000380538	H7BYE3 [Direct mapping] ADAMTS-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	150 aa 15.9 kDa	No	0

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