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IMPDH2

GENERAL INFORMATION

Gene name

 IMPDH2

Gene description

 IMP (inosine 5'-monophosphate) dehydrogenase 2

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 2 antibodies.
HPA001400 , CAB020717
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA001400
CAB020717

GENE INFORMATION

Gene name

 IMPDH2

Synonyms

Description

 IMP (inosine 5'-monophosphate) dehydrogenase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 49024325 - 49029408

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178035 (version 83.38)

Entrez gene

 3615

UniProt

 P12268 (UniProt - Evidence at protein level)

neXtProt

 NX_P12268

Antibodypedia

 IMPDH2 antibodies

PROTEIN BROWSER
IMPDH2-001
IMPDH2-006
IMPDH2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IMPDH2-001
ENSP00000321584
ENST00000326739
P12268 [Direct mapping]
Inosine-5'-monophosphate dehydrogenase 2
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003824 [catalytic activity]
GO:0003938 [IMP dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005778 [peroxisomal membrane]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006177 [GMP biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0044281 [small molecule metabolic process]
GO:0046651 [lymphocyte proliferation]
GO:0046872 [metal ion binding]
GO:0051289 [protein homotetramerization]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0060041 [retina development in camera-type eye]
GO:0070062 [extracellular exosome]
GO:0071353 [cellular response to interleukin-4]
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 514 aa
55.8 kDa 		No 0
IMPDH2-006
ENSP00000393525
ENST00000429182
H0Y4R1 [Direct mapping]
Inosine-5'-monophosphate dehydrogenase 2
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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003938 [IMP dehydrogenase activity]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 470 aa
51 kDa 		No 0
IMPDH2-010
ENSP00000403502
ENST00000442157
E7ETK5 [Direct mapping]
Inosine-5'-monophosphate dehydrogenase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0055114 [oxidation-reduction process]
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 279 aa
30.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.