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ALS2CL

GENERAL INFORMATION

Gene name

 ALS2CL

Gene description

 ALS2 C-terminal like

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CAPAN-2, HaCaT, hTCEpi, RT4, SiHa)
HPA (normal tissue):Tissue enhanced (skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA048301 , CAB046465
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048301
CAB046465

GENE INFORMATION

Gene name

 ALS2CL (HGNC Symbol)

Synonyms

 DKFZp686I0110, FLJ36525, RN49018

Description

 ALS2 C-terminal like (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 46668997 - 46693704

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178038 (version 83.38)

Entrez gene

 259173

UniProt

 Q60I27 (UniProt - Evidence at protein level)

neXtProt

 NX_Q60I27

Antibodypedia

 ALS2CL antibodies

PROTEIN BROWSER
ALS2CL-001
ALS2CL-002
ALS2CL-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALS2CL-001
ENSP00000313670
ENST00000318962
Q60I27 [Direct mapping]
ALS2 C-terminal-like protein
A0A024R2U1 [Target identity:100%; Query identity:100%]
ALS2 C-terminal like, isoform CRA_c
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   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0007032 [endosome organization]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0042802 [identical protein binding]
GO:0043547 [positive regulation of GTPase activity]
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 953 aa
107.7 kDa 		No 0
ALS2CL-002
ENSP00000413223
ENST00000415953
Q60I27 [Direct mapping]
ALS2 C-terminal-like protein
A0A024R2U1 [Target identity:100%; Query identity:100%]
ALS2 C-terminal like, isoform CRA_c
Show all
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0007032 [endosome organization]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0042802 [identical protein binding]
GO:0043547 [positive regulation of GTPase activity]
Show all
 953 aa
107.7 kDa 		No 0
ALS2CL-008
ENSP00000373248
ENST00000383742
Q60I27 [Direct mapping]
ALS2 C-terminal-like protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005737 [cytoplasm]
GO:0007032 [endosome organization]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0042802 [identical protein binding]
GO:0043547 [positive regulation of GTPase activity]
Show all
 300 aa
35 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.