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MLF1

GENERAL INFORMATION

Gene name

 MLF1

Gene description

 Myeloid leukemia factor 1

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and stomach cancer (unfavourable).
Endometrial cancer p<0.001
Stomach cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MLF1

Synonyms

Description

 Myeloid leukemia factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

Chromosome

 3

Cytoband

 q25.32

Chromosome location (bp)

 158571163 - 158607252

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000178053 (version 83.38)

Entrez gene

 4291

UniProt

 P58340 (UniProt - Evidence at protein level)

neXtProt

 NX_P58340

Antibodypedia

 MLF1 antibodies

PROTEIN BROWSER
«
MLF1-001
MLF1-002
MLF1-004
MLF1-005
MLF1-006
MLF1-007
MLF1-008
MLF1-009
MLF1-013
MLF1-014
MLF1-015
MLF1-201
MLF1-202
MLF1-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MLF1-001
ENSP00000348157
ENST00000355893
P58340 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002318 [myeloid progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0019904 [protein domain specific binding]
Show all
 268 aa
30.6 kDa 		No 0
MLF1-002
ENSP00000420134
ENST00000471745
P58340 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002318 [myeloid progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0019904 [protein domain specific binding]
Show all
 258 aa
29.1 kDa 		No 0
MLF1-004
ENSP00000352025
ENST00000359117
P58340 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002318 [myeloid progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0019904 [protein domain specific binding]
Show all
 243 aa
27.6 kDa 		No 0
MLF1-005
ENSP00000417835
ENST00000484955
P58340 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002318 [myeloid progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0019904 [protein domain specific binding]
Show all
 243 aa
27.6 kDa 		No 0
MLF1-006
ENSP00000418595
ENST00000469452
P58340 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002318 [myeloid progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0019904 [protein domain specific binding]
Show all
 200 aa
23.1 kDa 		No 0
MLF1-007
ENSP00000417141
ENST00000482628
P58340 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002318 [myeloid progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0019904 [protein domain specific binding]
Show all
 243 aa
27.6 kDa 		No 0
MLF1-008
ENSP00000417777
ENST00000478894
P58340 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002318 [myeloid progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0019904 [protein domain specific binding]
Show all
 258 aa
29.1 kDa 		No 0
MLF1-009
ENSP00000419636
ENST00000498592
C9K0D4 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 188 aa
21.4 kDa 		No 0
MLF1-013
ENSP00000419637
ENST00000477042
C9K0D3 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 174 aa
19.5 kDa 		No 0
MLF1-014
ENSP00000417278
ENST00000466246
C9J3M3 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 204 aa
23.1 kDa 		No 0
MLF1-015
ENSP00000420410
ENST00000491767
C9JNE5 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 191 aa
21.7 kDa 		No 0
MLF1-201
ENSP00000376568
ENST00000392822
P58340 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002318 [myeloid progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0019904 [protein domain specific binding]
Show all
 299 aa
33.9 kDa 		No 0
MLF1-202
ENSP00000484169
ENST00000618075
P58340 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002318 [myeloid progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0019904 [protein domain specific binding]
Show all
 200 aa
23.1 kDa 		No 0
MLF1-203
ENSP00000483337
ENST00000619577
P58340 [Direct mapping]
Myeloid leukemia factor 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002318 [myeloid progenitor cell differentiation]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007050 [cell cycle arrest]
GO:0019904 [protein domain specific binding]
Show all
 258 aa
29.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.