Expression of BOLA1 in cancer - Summary - The Human Protein Atlas

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BOLA1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BOLA1
Gene description	BolA family member 1
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA007005
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and ovarian cancer (favourable).
Liver cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007005

GENE INFORMATION
Gene name	BOLA1 (HGNC Symbol)
Synonyms	CGI-143
Description	BolA family member 1 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q21.2
Chromosome location (bp)	149887890 - 149900798
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178096 (version 83.38)
Entrez gene	51027
UniProt	Q9Y3E2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3E2
Antibodypedia	BOLA1 antibodies

PROTEIN BROWSER

BOLA1-001	BOLA1-002	BOLA1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BOLA1-001 ENSP00000358148 ENST00000369152	Q9Y3E2 [Direct mapping] BolA-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	137 aa 14.3 kDa	Yes	0
BOLA1-002 ENSP00000358149 ENST00000369153	Q9Y3E2 [Direct mapping] BolA-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005739 [mitochondrion] Show all	137 aa 14.3 kDa	Yes	0
BOLA1-003 ENSP00000358146 ENST00000369150	Q9Y3E2 [Direct mapping] BolA-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	137 aa 14.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.