Expression of DALRD3 in cancer - Summary - The Human Protein Atlas

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DALRD3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DALRD3
Gene description	DALR anticodon binding domain containing 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA036862
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036862

GENE INFORMATION
Gene name	DALRD3 (HGNC Symbol)
Synonyms	FLJ10496
Description	DALR anticodon binding domain containing 3 (HGNC Symbol)
Entrez gene summary	The exact function of this gene is not known. It encodes a protein with a DALR anticodon binding domain similar to that of class Ia aminoacyl tRNA synthetases. This gene is located in a cluster of genes (with a complex sense-anti-sense genome architecture) on chromosome 3, and contains two micro RNA (miRNA) precursors (mir-425 and mir-191) in one of its introns. Preferential expression of this gene (the miRNAs and other genes in the cluster) in testis suggests a role of this gene in spermatogenesis (PMID:19906709). [provided by RefSeq, Feb 2013]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49015488 - 49022293
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178149 (version 83.38)
Entrez gene	55152
UniProt	Q5D0E6 (UniProt - Evidence at protein level)
neXtProt	NX_Q5D0E6
Antibodypedia	DALRD3 antibodies

PROTEIN BROWSER

DALRD3-002	DALRD3-003	DALRD3-007	DALRD3-008	DALRD3-011	DALRD3-015	DALRD3-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DALRD3-002 ENSP00000344989 ENST00000341949	Q5D0E6 [Direct mapping] DALR anticodon-binding domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004814 [arginine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006420 [arginyl-tRNA aminoacylation] Show all	543 aa 59.4 kDa	No	0
DALRD3-003 ENSP00000410623 ENST00000441576	Q5D0E6 [Direct mapping] DALR anticodon-binding domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004814 [arginine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006420 [arginyl-tRNA aminoacylation] Show all	516 aa 55.5 kDa	No	0
DALRD3-007 ENSP00000403770 ENST00000440857	C9JJG6 [Direct mapping] DALR anticodon-binding domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004814 [arginine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0006420 [arginyl-tRNA aminoacylation] Show all	386 aa 42.2 kDa	No	0
DALRD3-008 ENSP00000323265 ENST00000313778	Q5D0E6 [Direct mapping] DALR anticodon-binding domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004814 [arginine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006420 [arginyl-tRNA aminoacylation] Show all	376 aa 41.6 kDa	No	0
DALRD3-011 ENSP00000396650 ENST00000438585	H7C0T8 [Direct mapping] DALR anticodon-binding domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004814 [arginine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006420 [arginyl-tRNA aminoacylation] Show all	184 aa 20.5 kDa	No	0
DALRD3-015 ENSP00000397385 ENST00000420952	C9JA38 [Direct mapping] DALR anticodon-binding domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		294 aa 31.9 kDa	No	0
DALRD3-016 ENSP00000485305 ENST00000496568	A0A096LNZ3 [Direct mapping] DALR anticodon-binding domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 8 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.