Expression of LCORL in cancer - Summary - The Human Protein Atlas

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LCORL

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LCORL
Gene description	Ligand dependent nuclear receptor corepressor-like
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA028794 , HPA028795
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028794	HPA028795

GENE INFORMATION
Gene name	LCORL (HGNC Symbol)
Synonyms	FLJ30696, MLR1
Description	Ligand dependent nuclear receptor corepressor-like (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Chromosome	4
Cytoband	p15.31
Chromosome location (bp)	17841199 - 18021876
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000178177 (version 83.38)
Entrez gene	254251
UniProt	Q8N3X6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N3X6
Antibodypedia	LCORL antibodies

PROTEIN BROWSER

LCORL-001	LCORL-002	LCORL-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LCORL-001 ENSP00000317566 ENST00000326877	Q8N3X6 [Direct mapping] Ligand-dependent nuclear receptor corepressor-like protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] Show all	318 aa 35.4 kDa	Yes	0
LCORL-002 ENSP00000371659 ENST00000382224	C9JI46 [Direct mapping] Ligand-dependent nuclear receptor corepressor-like protein; Transcription factor MLR1, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] Show all	518 aa 57.5 kDa	No	0
LCORL-201 ENSP00000371661 ENST00000382226	Q8N3X6 [Direct mapping] Ligand-dependent nuclear receptor corepressor-like protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] Show all	602 aa 67 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.