Expression of RNF212 in cancer - Summary - The Human Protein Atlas

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RNF212

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RNF212
Gene description	Ring finger protein 212
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A-431, HeLa, SiHa)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA057527
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057527

GENE INFORMATION
Gene name	RNF212 (HGNC Symbol)
Synonyms	FLJ38841, LOC285498
Description	Ring finger protein 212 (HGNC Symbol)
Entrez gene summary	This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	1056250 - 1113562
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000178222 (version 83.38)
Entrez gene	285498
UniProt	Q495C1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q495C1
Antibodypedia	RNF212 antibodies

PROTEIN BROWSER

RNF212-001	RNF212-002	RNF212-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNF212-001 ENSP00000372428 ENST00000382968	Q495C1 [Direct mapping] Probable E3 SUMO-protein ligase RNF212 Show all	Predicted intracellular proteins Show all	GO:0000795 [synaptonemal complex] GO:0005515 [protein binding] GO:0006311 [meiotic gene conversion] GO:0007131 [reciprocal meiotic recombination] GO:0008270 [zinc ion binding] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0051026 [chiasma assembly] Show all	232 aa 26.4 kDa	No	0
RNF212-002 ENSP00000389709 ENST00000433731	Q495C1 [Direct mapping] Probable E3 SUMO-protein ligase RNF212 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0000795 [synaptonemal complex] GO:0005515 [protein binding] GO:0006311 [meiotic gene conversion] GO:0007131 [reciprocal meiotic recombination] GO:0008270 [zinc ion binding] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0051026 [chiasma assembly] Show all	297 aa 33.4 kDa	No	0
RNF212-004 ENSP00000327481 ENST00000333673	Q495C1 [Direct mapping] Probable E3 SUMO-protein ligase RNF212 Show all	Predicted intracellular proteins Show all	GO:0000795 [synaptonemal complex] GO:0005515 [protein binding] GO:0006311 [meiotic gene conversion] GO:0007131 [reciprocal meiotic recombination] GO:0008270 [zinc ion binding] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0051026 [chiasma assembly] Show all	273 aa 30.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.